GLIPR1 GLI pathogenesis related 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GLIPR1provided by HGNC
Official Full Name: GLI pathogenesis related 1provided by HGNC
Primary source: HGNC:HGNC:17001
See related: Ensembl:ENSG00000139278 MIM:602692; AllianceGenome:HGNC:17001
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GLIPR; RTVP1; CRISP7
Summary: This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in appendix (RPKM 29.8), gall bladder (RPKM 25.1) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q21.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (75480755..75503863)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (75455443..75478551)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (75874535..75897643)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Combined therapy of CAR-IL-15/IL-15Ralpha-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer.
Title: Combined therapy of CAR-IL-15/IL-15Rα-T cells and GLIPR1 knockdown in cancer cells enhanced anti-tumor effect against gastric cancer.
GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway.
Title: GLIPR1 promotes proliferation, metastasis and 5-fluorouracil resistance in hepatocellular carcinoma by activating the PI3K/PDK1/ROCK1 pathway.
Glioma pathogenesis-related protein 1 performs dual functions in tumor cells.
Title: Glioma pathogenesis-related protein 1 performs dual functions in tumor cells.
GLIPR1 and SPARC expression profile reveals a signature associated with prostate Cancer Brain metastasis.
Title: GLIPR1 and SPARC expression profile reveals a signature associated with prostate Cancer Brain metastasis.
Study demonstrates that GLIPR1 expression is frequently reduced in the plasma cells of multiple myeloma (MM)patients. Functional results in MM cell lines and in vivo suggest that GLIPR1 is unlikely to be a potent tumor suppressor in MM.
Title: GLIPR1 expression is reduced in multiple myeloma but is not a tumour suppressor in mice.
Data found that GLIPR1 expression level was low in human bladder cancer tissues. Also, GLIPR1 was shown to inhibit the expression of TPX2.
Title: TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer.
High GLIPR1 expression is associated with cisplatin resistance in lung cancer.
Title: GLIPR1 modulates the response of cisplatin-resistant human lung cancer cells to cisplatin.
The present study identified GLIPR1 and miR-16 as key components for regulating the proliferation, migration, invasion and cancer-initiating cells in osteosarcoma
Title: GLIPR1 inhibits the proliferation and induces the differentiation of cancer-initiating cells by regulating miR-16 in osteosarcoma.
This study reveals a novel pathway that PRMT5/WDR77 regulates GLIPR1 expression to control lung cancer cell growth.
Title: GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer.
Overexpression of RTVP-1 in human neural stem cells induced mesenchymal differentiation, whereas silencing of RTVP-1 in glioma stem cells (GSCs) decreased the mesenchymal transformation and stemness of these cells.
Title: RTVP-1 promotes mesenchymal transformation of glioma via a STAT-3/IL-6-dependent positive feedback loop.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-56842 (e-PCR)
- UniSTS:25604

STS-H56474 (e-PCR)
- UniSTS:29485

STS-N32834 (e-PCR)
- UniSTS:23087

D12S1480E (e-PCR)
- UniSTS:153934

RH18004 (e-PCR)
- UniSTS:70991

RH149 (e-PCR)
- UniSTS:25945

SGC32697 (e-PCR)
- UniSTS:45678

RH46985 (e-PCR)
- UniSTS:67458

RH46456 (e-PCR)
- UniSTS:32917

SHGC-35465 (e-PCR)
- UniSTS:17316

G35331 (e-PCR)
- UniSTS:79550

SHGC-31221 (e-PCR)
- UniSTS:52196

RH102666 (e-PCR)
- UniSTS:97000

D20S989 (e-PCR)
- UniSTS:154601

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in azurophil granule membrane	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	HDA more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: glioma pathogenesis-related protein 1

Names: GLI pathogenesis-related 1 (glioma); gliPR 1; protein RTVP-1; related to testis-specific, vespid, and pathogenesis proteins 1; testes-specific vespid and pathogenesis protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006851.3 → NP_006842.2 glioma pathogenesis-related protein 1 precursor

See identical proteins and their annotated locations for NP_006842.2

Status: REVIEWED

Source sequence(s)

AC022507, AC121761, BC012510, CA421777, CB123261

Consensus CDS

CCDS9011.1

UniProtKB/Swiss-Prot

A7YET6, F8VUC2, P48060, Q15409, Q969K2

Related

ENSP00000266659.3, ENST00000266659.8

Conserved Domains (1) summary

cd05385
Location:32 → 178

SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...