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GLIPR1 GLI pathogenesis related 1 [ Homo sapiens (human) ]

Gene ID: 11010, updated on 26-Apr-2020

Summary

Official Symbol
GLIPR1provided by HGNC
Official Full Name
GLI pathogenesis related 1provided by HGNC
Primary source
HGNC:HGNC:17001
See related
Ensembl:ENSG00000139278 MIM:602692
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLIPR; RTVP1; CRISP7
Summary
This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 29.8), gall bladder (RPKM 25.1) and 24 other tissues See more
Orthologs

Genomic context

See GLIPR1 in Genome Data Viewer
Location:
12q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (75480754..75503863)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75874513..75895716)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcyphosine 2 Neighboring gene GLIPR1 like 1 Neighboring gene GLIPR1 like 2 Neighboring gene uncharacterized LOC105369844 Neighboring gene KRR1 small subunit processome component homolog Neighboring gene uncharacterized LOC107984533 Neighboring gene phosphogluconate dehydrogenase pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
neutrophil degranulation TAS
Traceable Author Statement
more info
 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glioma pathogenesis-related protein 1
Names
GLI pathogenesis-related 1 (glioma)
gliPR 1
protein RTVP-1
related to testis-specific, vespid, and pathogenesis proteins 1
testes-specific vespid and pathogenesis protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006851.3NP_006842.2  glioma pathogenesis-related protein 1 precursor

    See identical proteins and their annotated locations for NP_006842.2

    Status: REVIEWED

    Source sequence(s)
    AC022507, AC121761, BC012510, CA421777, CB123261
    Consensus CDS
    CCDS9011.1
    UniProtKB/Swiss-Prot
    P48060
    Related
    ENSP00000266659.3, ENST00000266659.8
    Conserved Domains (1) summary
    cd05385
    Location:32178
    SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    75480754..75503863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537775.2XP_011536077.1  glioma pathogenesis-related protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011536077.1

    Related
    ENSP00000391144.3, ENST00000456650.7
    Conserved Domains (1) summary
    cl00133
    Location:32141
    SCP; SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in ...
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