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GLIPR1 GLI pathogenesis related 1 [ Homo sapiens (human) ]

Gene ID: 11010, updated on 20-Nov-2022

Summary

Official Symbol
GLIPR1provided by HGNC
Official Full Name
GLI pathogenesis related 1provided by HGNC
Primary source
HGNC:HGNC:17001
See related
Ensembl:ENSG00000139278 MIM:602692; AllianceGenome:HGNC:17001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLIPR; RTVP1; CRISP7
Summary
This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate cancer. The protein has proapoptotic activities in prostate and bladder cancer cells. This gene is a member of a cluster on chromosome 12 containing two other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 29.8), gall bladder (RPKM 25.1) and 24 other tissues See more
Orthologs
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Genomic context

See GLIPR1 in Genome Data Viewer
Location:
12q21.2
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (75480755..75503863)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (75455443..75478551)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75874535..75897643)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcyphosine 2 Neighboring gene uncharacterized LOC124902968 Neighboring gene GLIPR1 like 1 Neighboring gene GLIPR1 like 2 Neighboring gene GLIPR1 antisense RNA 1 Neighboring gene uncharacterized LOC105369844 Neighboring gene KRR1 small subunit processome component homolog Neighboring gene uncharacterized LOC107984533 Neighboring gene phosphogluconate dehydrogenase pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in azurophil granule membrane TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glioma pathogenesis-related protein 1
Names
GLI pathogenesis-related 1 (glioma)
gliPR 1
protein RTVP-1
related to testis-specific, vespid, and pathogenesis proteins 1
testes-specific vespid and pathogenesis protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006851.3NP_006842.2  glioma pathogenesis-related protein 1 precursor

    See identical proteins and their annotated locations for NP_006842.2

    Status: REVIEWED

    Source sequence(s)
    AC022507, AC121761, BC012510, CA421777, CB123261
    Consensus CDS
    CCDS9011.1
    UniProtKB/Swiss-Prot
    P48060, Q969K2
    Related
    ENSP00000266659.3, ENST00000266659.8
    Conserved Domains (1) summary
    cd05385
    Location:32178
    SCP_GLIPR-1_like; SCP_GLIPR-1_like: SCP-like extracellular protein domain, glioma pathogenesis-related protein (GLIPR)-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    75480755..75503863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428131.1XP_047284087.1  glioma pathogenesis-related protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    75455443..75478551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)