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CHAD chondroadherin [ Homo sapiens (human) ]

Gene ID: 1101, updated on 21-Dec-2019

Summary

Official Symbol
CHADprovided by HGNC
Official Full Name
chondroadherinprovided by HGNC
Primary source
HGNC:HGNC:1909
See related
Ensembl:ENSG00000136457 MIM:602178
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLRR4A
Summary
Chondroadherin is a cartilage matrix protein thought to mediate adhesion of isolated chondrocytes. The protein contains 11 leucine-rich repeats flanked by cysteine-rich regions. The chondroadherin messenger RNA is present in chondrocytes at all ages. [provided by RefSeq, Jul 2008]
Expression
Broad expression in small intestine (RPKM 4.5), liver (RPKM 4.4) and 24 other tissues See more
Orthologs

Genomic context

See CHAD in Genome Data Viewer
Location:
17q21.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50464492..50469881, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48541853..48547242, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene essential meiotic structure-specific endonuclease 1 Neighboring gene leucine rich repeat containing 59 Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 9 Neighboring gene Sharpr-MPRA regulatory region 9450 Neighboring gene radical S-adenosyl methionine domain containing 1 Neighboring gene MYCBP associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
bone development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of bone trabecula formation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
chondroadherin
Names
cartilage leucine-rich protein
chondroadherin proteoglycan

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267.3NP_001258.2  chondroadherin precursor

    See identical proteins and their annotated locations for NP_001258.2

    Status: REVIEWED

    Source sequence(s)
    AC021491, BC036360, BC073974
    Consensus CDS
    CCDS11568.1
    UniProtKB/Swiss-Prot
    O15335
    Related
    ENSP00000423812.1, ENST00000508540.6
    Conserved Domains (5) summary
    smart00082
    Location:300347
    LRRCT; Leucine rich repeat C-terminal domain
    COG4886
    Location:106301
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:5376
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01462
    Location:2349
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:75135
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    50464492..50469881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524214.2XP_011522516.1  chondroadherin isoform X1

    See identical proteins and their annotated locations for XP_011522516.1

    Related
    ENSP00000258969.4, ENST00000258969.4
    Conserved Domains (5) summary
    smart00082
    Location:381428
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:171363
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:134157
    LRR_RI; leucine-rich repeat [structural motif]
    pfam01462
    Location:104130
    LRRNT; Leucine rich repeat N-terminal domain
    pfam13855
    Location:156216
    LRR_8; Leucine rich repeat
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