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Pygl liver glycogen phosphorylase [ Mus musculus (house mouse) ]

Gene ID: 110095, updated on 5-Mar-2024

Summary

Official Symbol
Pyglprovided by MGI
Official Full Name
liver glycogen phosphorylaseprovided by MGI
Primary source
MGI:MGI:97829
See related
Ensembl:ENSMUSG00000021069 AllianceGenome:MGI:97829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables glycogen phosphorylase activity. Acts upstream of or within glycogen metabolic process; necroptotic process; and response to bacterium. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; cranium; sensory organ; and urinary system. Used to study glycogen storage disease VI. Human ortholog(s) of this gene implicated in glycogen storage disease; glycogen storage disease VI; and lactic acidosis. Orthologous to human PYGL (glycogen phosphorylase L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 115.1), liver E18 (RPKM 102.5) and 12 other tissues See more
Orthologs
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Genomic context

See Pygl in Genome Data Viewer
Location:
12 C2; 12 29.01 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (70237589..70274457, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (70190815..70227683, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:71246077-71246378 Neighboring gene predicted gene, 53726 Neighboring gene abhydrolase domain containing 12B Neighboring gene STARR-seq mESC enhancer starr_32387 Neighboring gene RIKEN cDNA F730035M05 gene Neighboring gene STARR-seq mESC enhancer starr_32388 Neighboring gene predicted gene, 38467 Neighboring gene tripartite motif-containing 9 Neighboring gene STARR-seq mESC enhancer starr_32389

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (5) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables SHG alpha-glucan phosphorylase activity IEA
Inferred from Electronic Annotation
more info
 
enables bile acid binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables glucose binding ISO
Inferred from Sequence Orthology
more info
 
enables glycogen phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycogen phosphorylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycogen phosphorylase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables linear malto-oligosaccharide phosphorylase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables purine nucleobase binding ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables vitamin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glycogen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within necroptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glycogen phosphorylase, liver form
NP_573461.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133198.2NP_573461.2  glycogen phosphorylase, liver form

    See identical proteins and their annotated locations for NP_573461.2

    Status: VALIDATED

    Source sequence(s)
    AK145989, BY435276
    Consensus CDS
    CCDS25957.1
    UniProtKB/Swiss-Prot
    Q3UKJ0, Q9ET01
    UniProtKB/TrEMBL
    Q91WP9
    Related
    ENSMUSP00000071231.7, ENSMUST00000071250.13
    Conserved Domains (2) summary
    cd04300
    Location:29827
    GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...
    TIGR02093
    Location:32827
    P_ylase; glycogen/starch/alpha-glucan phosphorylases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    70237589..70274457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)