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HTD2 hydroxyacyl-thioester dehydratase type 2 [ Homo sapiens (human) ]

Gene ID: 109703458, updated on 23-Nov-2021

Summary

Official Symbol
HTD2provided by HGNC
Official Full Name
hydroxyacyl-thioester dehydratase type 2provided by HGNC
Primary source
HGNC:HGNC:53111
See related
Ensembl:ENSG00000255154
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein that localizes to the mitochondria and can function as a 3-hydroxyacyl thioester dehydratase. This gene is located just downstream of the gene for ribonuclease P/MRP subunit p14 (RPP14) in a genomic context that is conserved among animals. The upstream RPP14 gene is thought to be co-transcribed with this gene, and bicistronic transcripts may include open reading frames for both proteins. [provided by RefSeq, May 2017]
Orthologs
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Genomic context

See HTD2 in Genome Data Viewer
Location:
3p14.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (58306245..58320193)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (58291972..58305920)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986091 Neighboring gene abhydrolase domain containing 6, acylglycerol lipase Neighboring gene ribonuclease P/MRP subunit p14 Neighboring gene uncharacterized LOC105377106 Neighboring gene PX domain containing serine/threonine kinase like Neighboring gene pyruvate dehydrogenase E1 subunit beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

General protein information

Preferred Names
hydroxyacyl-thioester dehydratase type 2, mitochondrial
Names
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
NP_001335641.1
NP_001335642.1
NP_001335643.1
NP_001335644.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348712.2NP_001335641.1  hydroxyacyl-thioester dehydratase type 2, mitochondrial

    Status: REVIEWED

    Source sequence(s)
    AC098479
    Consensus CDS
    CCDS87096.1
    UniProtKB/Swiss-Prot
    P86397
    UniProtKB/TrEMBL
    L0R6P0
    Related
    ENSP00000484277.1, ENST00000461393.7
    Conserved Domains (1) summary
    cd03449
    Location:36162
    R_hydratase; (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase ...
  2. NM_001348713.1NP_001335642.1  hydroxyacyl-thioester dehydratase type 2, mitochondrial

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC098479
    Consensus CDS
    CCDS87096.1
    UniProtKB/Swiss-Prot
    P86397
    UniProtKB/TrEMBL
    L0R6P0
    Related
    ENSP00000481593.1, ENST00000477305.5
    Conserved Domains (1) summary
    cd03449
    Location:36162
    R_hydratase; (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase ...
  3. NM_001348714.1NP_001335643.1  hydroxyacyl-thioester dehydratase type 2, mitochondrial

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC098479
    Consensus CDS
    CCDS87096.1
    UniProtKB/Swiss-Prot
    P86397
    UniProtKB/TrEMBL
    L0R6P0
    Related
    ENSP00000482940.1, ENST00000481972.5
    Conserved Domains (1) summary
    cd03449
    Location:36162
    R_hydratase; (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase ...
  4. NM_001348715.1NP_001335644.1  hydroxyacyl-thioester dehydratase type 2, mitochondrial

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC098479
    Consensus CDS
    CCDS87096.1
    UniProtKB/Swiss-Prot
    P86397
    UniProtKB/TrEMBL
    L0R6P0
    Conserved Domains (1) summary
    cd03449
    Location:36162
    R_hydratase; (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    58306245..58320193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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