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Acy1 aminoacylase 1 [ Mus musculus (house mouse) ]

Gene ID: 109652, updated on 2-Nov-2024

Summary

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Official Symbol
Acy1provided by MGI
Official Full Name
aminoacylase 1provided by MGI
Primary source
MGI:MGI:87913
See related
Ensembl:ENSMUSG00000023262 AllianceGenome:MGI:87913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acy-1; 1110014J22Rik
Summary
Predicted to enable aminoacylase activity and identical protein binding activity. Predicted to be involved in amino acid metabolic process. Predicted to be located in extracellular exosome. Orthologous to human ACY1 (aminoacylase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in duodenum adult (RPKM 66.0), kidney adult (RPKM 51.7) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Acy1 in Genome Data Viewer
Location:
9 F1; 9 57.49 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106310180..106315594, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106432981..106438236, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33616 Neighboring gene predicted gene, 46131 Neighboring gene STARR-seq mESC enhancer starr_25150 Neighboring gene ribosomal protein L29 Neighboring gene STARR-positive B cell enhancer ABC_E11423 Neighboring gene abhydrolase domain containing 14A Neighboring gene abhydrolase domain containing 14b Neighboring gene poly(rC) binding protein 4 Neighboring gene G protein-coupled receptor 62

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metabolite profiling of CKD progression in the chronic renal insufficiency cohort study. Wen D, et al. JCI Insight, 2022 Oct 24. PMID 36048534, Free PMC Article
  2. Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure. Lai Q, et al. Acta Pharmacol Sin, 2022 Aug. PMID 34916608, Free PMC Article
  3. Bioautographic visualization of aminoacylase-1: assignment of the structural gene ACY-1 to chromosome 3 in man. Naylor SL, et al. Somatic Cell Genet, 1979 Jan. PMID 373141
  4. Aminoacylase 1 is a sphingosine kinase 1-interacting protein. Maceyka M, et al. FEBS Lett, 2004 Jun 18. PMID 15196915
  5. Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma. Benson MD, et al. Cell Metab, 2023 Sep 5. PMID 37582364, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure.
    Title: Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminoacylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacylase activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacylase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aminoacylase-1
Names
N-acyl-L-amino-acid amidohydrolase
NP_001263371.1
NP_079647.1
XP_036010451.1
XP_036010452.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276442.1 → NP_001263371.1  aminoacylase-1

    See identical proteins and their annotated locations for NP_001263371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK003703, BX529990, CV560337
    Consensus CDS
    CCDS23477.1
    UniProtKB/Swiss-Prot
    Q99JW2, Q9CR15
    UniProtKB/TrEMBL
    A0A0R4J050
    Related
    ENSMUST00000190851.3
    Conserved Domains (2) summary
    cd05646
    Location:9 → 399
    M20_AcylaseI_like; M20 Aminoacylase-I like subfamily
    TIGR01880
    Location:1 → 401
    Ac-peptdase-euk; N-acyl-L-amino-acid amidohydrolase

  2. NM_025371.3 → NP_079647.1  aminoacylase-1

    See identical proteins and their annotated locations for NP_079647.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK003703, BX529990
    Consensus CDS
    CCDS23477.1
    UniProtKB/Swiss-Prot
    Q99JW2, Q9CR15
    UniProtKB/TrEMBL
    A0A0R4J050
    Related
    ENSMUSP00000024031.7, ENSMUST00000024031.13
    Conserved Domains (2) summary
    cd05646
    Location:9 → 399
    M20_AcylaseI_like; M20 Aminoacylase-I like subfamily
    TIGR01880
    Location:1 → 401
    Ac-peptdase-euk; N-acyl-L-amino-acid amidohydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106310180..106315594 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154558.1 → XP_036010451.1  aminoacylase-1 isoform X1

    UniProtKB/TrEMBL
    A0A1L1SS90
    Conserved Domains (1) summary
    cl14876
    Location:2 → 312
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

  2. XM_036154559.1 → XP_036010452.1  aminoacylase-1 isoform X1

    UniProtKB/TrEMBL
    A0A1L1SS90
    Conserved Domains (1) summary
    cl14876
    Location:2 → 312
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99JW2.1 GenPept UniProtKB/Swiss-Prot:Q99JW2

Gene LinkOut

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