Format

Send to:

Choose Destination

TOMM34 translocase of outer mitochondrial membrane 34 [ Homo sapiens (human) ]

Gene ID: 10953, updated on 1-Jun-2020

Summary

Official Symbol
TOMM34provided by HGNC
Official Full Name
translocase of outer mitochondrial membrane 34provided by HGNC
Primary source
HGNC:HGNC:15746
See related
Ensembl:ENSG00000025772 MIM:616049
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOM34; URCC3; HTOM34P
Summary
The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 58.9), adrenal (RPKM 15.3) and 22 other tissues See more
Orthologs

Genomic context

See TOMM34 in Genome Data Viewer
Location:
20q13.12
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (44942130..44960425, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43570771..43589114, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta Neighboring gene poly(A) binding protein cytoplasmic 1 like Neighboring gene STK4 antisense RNA 1 (head to head) Neighboring gene serine/threonine kinase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein targeting to mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
mitochondrial import receptor subunit TOM34
Names
hTom34
outer mitochondrial membrane translocase (34kD)
translocase of outer membrane 34 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006809.5NP_006800.2  mitochondrial import receptor subunit TOM34

    See identical proteins and their annotated locations for NP_006800.2

    Status: REVIEWED

    Source sequence(s)
    BC001763, BC006573, BC007423, BI560064
    Consensus CDS
    CCDS13340.1
    UniProtKB/Swiss-Prot
    Q15785
    Related
    ENSP00000361900.3, ENST00000372813.4
    Conserved Domains (2) summary
    sd00006
    Location:193221
    TPR; TPR repeat [structural motif]
    cl26005
    Location:12294
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    44942130..44960425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260254.2XP_005260311.1  mitochondrial import receptor subunit TOM34 isoform X3

    See identical proteins and their annotated locations for XP_005260311.1

    Conserved Domains (3) summary
    sd00006
    Location:91119
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:127158
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:90155
    TPR_11; TPR repeat
  2. XM_011528501.1XP_011526803.1  mitochondrial import receptor subunit TOM34 isoform X1

    Conserved Domains (3) summary
    sd00006
    Location:167195
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:203234
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:166231
    TPR_11; TPR repeat
  3. XM_017027600.2XP_016883089.1  mitochondrial import receptor subunit TOM34 isoform X2

    Conserved Domains (3) summary
    smart00028
    Location:88117
    TPR; Tetratricopeptide repeats
    sd00006
    Location:937
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:1082
    TPR_11; TPR repeat

RNA

  1. XR_244131.3 RNA Sequence

Support Center