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SEC61B SEC61 translocon subunit beta [ Homo sapiens (human) ]

Gene ID: 10952, updated on 1-Jun-2020

Summary

Official Symbol
SEC61Bprovided by HGNC
Official Full Name
SEC61 translocon subunit betaprovided by HGNC
Primary source
HGNC:HGNC:16993
See related
Ensembl:ENSG00000106803 MIM:609214
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 68.2), appendix (RPKM 66.5) and 25 other tissues See more
Orthologs

Genomic context

See SEC61B in Genome Data Viewer
Location:
9q22.33
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (99222282..99230615)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (101984570..101992901)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 794, pseudogene Neighboring gene ALG2 alpha-1,3/1,6-mannosyltransferase Neighboring gene RN7SK pseudogene 225 Neighboring gene keratin 8 pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ARF guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding HDA PubMed 
epidermal growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Sec61 translocon complex IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum Sec complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum Sec complex ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein transport protein Sec61 subunit beta
Names
SEC61 translocon beta subunit
Sec61 beta subunit
Sec61 complex, beta subunit
protein translocation complex beta
protein transport protein SEC61 beta subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006808.3NP_006799.1  protein transport protein Sec61 subunit beta

    See identical proteins and their annotated locations for NP_006799.1

    Status: REVIEWED

    Source sequence(s)
    AL137067, BC001734
    Consensus CDS
    CCDS6741.1
    UniProtKB/Swiss-Prot
    P60468
    Related
    ENSP00000223641.4, ENST00000223641.5
    Conserved Domains (1) summary
    pfam03911
    Location:4891
    Sec61_beta; Sec61beta family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    99222282..99230615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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