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UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus [ Homo sapiens (human) ]

Gene ID: 10941, updated on 11-Jun-2021

Summary

Official Symbol
UGT2A1provided by HGNC
Official Full Name
UDP glucuronosyltransferase family 2 member A1 complex locusprovided by HGNC
Primary source
HGNC:HGNC:12542
See related
Ensembl:ENSG00000173610 MIM:604716
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UDPGT2A1
Summary
The protein encoded by this gene belongs to the UDP-glycosyltransferase family, members of which catalyze biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. [provided by RefSeq, Jul 2014]
Expression
Biased expression in kidney (RPKM 2.3), liver (RPKM 2.2) and 1 other tissue See more
Orthologs
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Genomic context

See UGT2A1 in Genome Data Viewer
Location:
4q13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (69588417..69653247, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70454135..70518965, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 2 member B4 Neighboring gene UDP glucuronosyltransferase family 2 member A3 pseudogene 7 Neighboring gene UDP glucuronosyltransferase family 2 member B7 pseudogene Neighboring gene UDP glucuronosyltransferase family 2 member A2 Neighboring gene sulfotransferase family 1B member 1 Neighboring gene sulfotransferase family 1D member 1, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in bile acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular glucuronidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of chemical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
UDP-glucuronosyltransferase 2A1
Names
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glycosyltransferase 2 family, polypeptide A1
uridine diphosphate glycosyltransferase 2 family, member A1
NP_001239203.2
NP_001239204.2
NP_001288168.1
NP_001376494.1
NP_006789.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252274.3NP_001239203.2  UDP-glucuronosyltransferase 2A1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AK304249, AK314209, BC142640, BE463677
    Consensus CDS
    CCDS58902.1
    UniProtKB/Swiss-Prot
    Q9Y4X1
    UniProtKB/TrEMBL
    A0A140T9Z0
    Related
    ENSP00000425497.1, ENST00000514019.1
    Conserved Domains (2) summary
    PHA03392
    Location:496670
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:237681
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
  2. NM_001252275.3NP_001239204.2  UDP-glucuronosyltransferase 2A1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AK304249, AK314209, BC142640, BE463677
    Consensus CDS
    CCDS58901.1
    UniProtKB/Swiss-Prot
    Q9Y4X1
    Related
    ENSP00000286604.4, ENST00000286604.8
    Conserved Domains (3) summary
    PHA03392
    Location:330504
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:21515
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    pfam13900
    Location:253289
    GVQW; Putative domain of unknown function
  3. NM_001301239.2NP_001288168.1  UDP-glucuronosyltransferase 2A1 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC093829, KF457774
    Consensus CDS
    CCDS77925.1
    UniProtKB/Swiss-Prot
    Q9Y4X1
    UniProtKB/TrEMBL
    D6RFW5
    Related
    ENSP00000421432.1, ENST00000512704.5
    Conserved Domains (2) summary
    PHA03392
    Location:286460
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:21471
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
  4. NM_001389565.1NP_001376494.1  UDP-glucuronosyltransferase 2A1 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC093829, KF457774
    Conserved Domains (1) summary
    pfam00201
    Location:237725
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
  5. NM_006798.5NP_006789.3  UDP-glucuronosyltransferase 2A1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006789.3

    Status: REVIEWED

    Source sequence(s)
    AJ006054, AK304249, AK314209, BC142640, BE463677
    Consensus CDS
    CCDS3529.1
    UniProtKB/Swiss-Prot
    Q9Y4X1
    Related
    ENSP00000424478.1, ENST00000503640.5
    Conserved Domains (2) summary
    PHA03392
    Location:266504
    egt; ecdysteroid UDP-glucosyltransferase; Provisional
    pfam00201
    Location:21515
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    69588417..69653247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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