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MORF4L1 mortality factor 4 like 1 [ Homo sapiens (human) ]

Gene ID: 10933, updated on 27-Nov-2022

Summary

Official Symbol
MORF4L1provided by HGNC
Official Full Name
mortality factor 4 like 1provided by HGNC
Primary source
HGNC:HGNC:16989
See related
Ensembl:ENSG00000185787 MIM:607303; AllianceGenome:HGNC:16989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15
Summary
Enables protein N-terminus binding activity. Involved in double-strand break repair via homologous recombination and histone modification. Located in nuclear speck. Part of NuA4 histone acetyltransferase complex and Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 192.5), brain (RPKM 119.7) and 25 other tissues See more
Orthologs
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Genomic context

See MORF4L1 in Genome Data Viewer
Location:
15q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (78872890..78898139)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (76736571..76761812)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (79165232..79190481)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903535 Neighboring gene tRNA-Lys (anticodon CTT) 1-2 Neighboring gene ribosomal protein L21 pseudogene 116 Neighboring gene RNA, U6 small nuclear 415, pseudogene Neighboring gene cathepsin H

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC10631

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H2A acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H2A acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone H4 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone acetylation IC
Inferred by Curator
more info
PubMed 
involved_in histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process IC
Inferred by Curator
more info
PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of double-strand break repair IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Sin3 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mortality factor 4-like protein 1
Names
Esa1p-associated factor 3 homolog
MORF-related gene 15 protein
MORF-related gene on chromosome 15
protein MSL3-1
transcription factor-like protein MRG15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001265603.2NP_001252532.1  mortality factor 4-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001252532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive internal exons and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3, 4 and 5 encode the same isoform (3), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC011944, AY148481, BG771854, BM996530, CX165647
    Consensus CDS
    CCDS58393.1
    UniProtKB/Swiss-Prot
    Q9UBU8
    Related
    ENSP00000452808.1, ENST00000558502.5
    Conserved Domains (1) summary
    pfam05712
    Location:57224
    MRG
  2. NM_001265604.2NP_001252533.1  mortality factor 4-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001252533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3, 4 and 5 encode the same isoform (3), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC011944, AC103975, AK300789, AY148481, BM996530, DB455429
    Consensus CDS
    CCDS58393.1
    UniProtKB/Swiss-Prot
    Q9UBU8
    Related
    ENSP00000452717.1, ENST00000559345.5
    Conserved Domains (1) summary
    pfam05712
    Location:57224
    MRG
  3. NM_001265605.2NP_001252534.1  mortality factor 4-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001252534.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at a downstream, in-frame start codon, compared to variant 1. Variants 3, 4 and 5 encode the same isoform (3), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC011944, AC103975, AY148481, BM996530, BX382045, DB455429
    Consensus CDS
    CCDS58393.1
    UniProtKB/Swiss-Prot
    Q9UBU8
    Conserved Domains (1) summary
    pfam05712
    Location:57224
    MRG
  4. NM_006791.4NP_006782.1  mortality factor 4-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC011944, AF100615, BM996530
    Consensus CDS
    CCDS32304.1
    UniProtKB/Swiss-Prot
    Q9UBU8
    Related
    ENSP00000408880.2, ENST00000426013.7
    Conserved Domains (2) summary
    cd18983
    Location:1571
    CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
    pfam05712
    Location:145312
    MRG
  5. NM_206839.3NP_996670.1  mortality factor 4-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_996670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is longer than isoform 1.
    Source sequence(s)
    AC011944, AY148481, BM996530
    Consensus CDS
    CCDS10307.1
    UniProtKB/Swiss-Prot
    Q9NSW5, Q9UBU8
    Related
    ENSP00000331310.5, ENST00000331268.9
    Conserved Domains (2) summary
    cd18983
    Location:15110
    CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins
    pfam05712
    Location:184351
    MRG

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    78872890..78898139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    76736571..76761812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)