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Mbd5 methyl-CpG binding domain protein 5 [ Mus musculus (house mouse) ]

Gene ID: 109241, updated on 5-Mar-2024

Summary

Official Symbol
Mbd5provided by MGI
Official Full Name
methyl-CpG binding domain protein 5provided by MGI
Primary source
MGI:MGI:2138934
See related
Ensembl:ENSMUSG00000036792 AllianceGenome:MGI:2138934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1630; 9430004D19Rik; C030040A15Rik
Summary
Predicted to enable chromatin binding activity. Acts upstream of or within glucose homeostasis; positive regulation of growth hormone receptor signaling pathway; and regulation of growth. Predicted to be located in midbody and nucleoplasm. Predicted to be active in chromocenter and nucleus. Is expressed in several structures, including brain; liver; small intestine; spinal cord; and spleen. Used to study autosomal dominant non-syndromic intellectual disability. Human ortholog(s) of this gene implicated in autism spectrum disorder and autosomal dominant non-syndromic intellectual disability 1. Orthologous to human MBD5 (methyl-CpG binding domain protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 3.0), cerebellum adult (RPKM 2.9) and 28 other tissues See more
Orthologs
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Genomic context

See Mbd5 in Genome Data Viewer
Location:
2 C1.1; 2 28.43 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (48839511..49209702)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (48949499..49319688)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene activin receptor IIA Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:48804892-48805001 Neighboring gene origin recognition complex, subunit 4 Neighboring gene predicted gene 13510 Neighboring gene adaptor-related protein complex 2, mu 1 subunit, pseudogene Neighboring gene STARR-seq mESC enhancer starr_04438 Neighboring gene 40S ribosomal protein S3a pseudogene Neighboring gene STARR-seq mESC enhancer starr_04439 Neighboring gene predicted gene, 25215

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in chromocenter IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromocenter ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
methyl-CpG-binding domain protein 5
Names
methyl-CpG-binding protein MBD5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290656.1NP_001277585.1  methyl-CpG-binding domain protein 5 isoform b

    See identical proteins and their annotated locations for NP_001277585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. The 5' UTR of this variant is incomplete due to a lack of full-length transcript support and splice pattern ambiguity in the upstream region.
    Source sequence(s)
    AL845298, AV298746, BQ551845, BU610422, BX546465, CB522230
    Consensus CDS
    CCDS71051.1
    UniProtKB/Swiss-Prot
    B1AYB6
    UniProtKB/TrEMBL
    Q69ZJ2
    Related
    ENSMUSP00000108374.2, ENSMUST00000112754.8
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:13871464
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  2. NM_029924.2NP_084200.1  methyl-CpG-binding domain protein 5 isoform a

    See identical proteins and their annotated locations for NP_084200.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). This variant has an inferred 5' UTR exon combination based on the mRNA AK155574.1.
    Source sequence(s)
    AK173176, AL845298, AL845521
    Consensus CDS
    CCDS38122.1
    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    48839511..49209702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157515.1XP_036013408.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  2. XM_030246630.2XP_030102490.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  3. XM_036157519.1XP_036013412.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  4. XM_030246635.2XP_030102495.1  methyl-CpG-binding domain protein 5 isoform X3

    UniProtKB/Swiss-Prot
    B1AYB6
    UniProtKB/TrEMBL
    Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:13871464
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  5. XM_036157520.1XP_036013413.1  methyl-CpG-binding domain protein 5 isoform X3

    UniProtKB/Swiss-Prot
    B1AYB6
    UniProtKB/TrEMBL
    Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:13871464
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  6. XM_036157511.1XP_036013404.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  7. XM_036157512.1XP_036013405.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  8. XM_030246625.2XP_030102485.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  9. XM_036157516.1XP_036013409.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  10. XM_036157513.1XP_036013406.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  11. XM_017314911.3XP_017170400.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  12. XM_030246624.1XP_030102484.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  13. XM_030246638.2XP_030102498.1  methyl-CpG-binding domain protein 5 isoform X4

    UniProtKB/TrEMBL
    F6Q8U1
    Related
    ENSMUSP00000119317.2, ENSMUST00000122841.8
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:12541293
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  14. XM_006497604.3XP_006497667.1  methyl-CpG-binding domain protein 5 isoform X2

    UniProtKB/TrEMBL
    Q69ZJ2
    Conserved Domains (1) summary
    cl02554
    Location:14981575
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  15. XM_030246629.2XP_030102489.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Related
    ENSMUSP00000036847.4, ENSMUST00000047413.10
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  16. XM_030246628.2XP_030102488.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

RNA

  1. XR_003950018.1 RNA Sequence

  2. XR_003950019.1 RNA Sequence