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Mbd5 methyl-CpG binding domain protein 5 [ Mus musculus (house mouse) ]

Gene ID: 109241, updated on 31-Jan-2019

Summary

Official Symbol
Mbd5provided by MGI
Official Full Name
methyl-CpG binding domain protein 5provided by MGI
Primary source
MGI:MGI:2138934
See related
Ensembl:ENSMUSG00000036792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1630; AA536666; AI426407; 9430004D19Rik; C030040A15Rik
Expression
Ubiquitous expression in frontal lobe adult (RPKM 3.0), cerebellum adult (RPKM 2.9) and 28 other tissues See more
Orthologs

Genomic context

See Mbd5 in Genome Data Viewer
Location:
2; 2 C1.1
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (48949490..49319690)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (48805028..49172589)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene activin receptor IIA Neighboring gene origin recognition complex, subunit 4 Neighboring gene ubiquitin-conjugating enzyme E2 D4-like Neighboring gene adaptor protein complex AP-2, mu1 pseudogene Neighboring gene 40S ribosomal protein S3a pseudogene Neighboring gene enhancer of polycomb homolog 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of growth hormone receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of behavior ISO
Inferred from Sequence Orthology
more info
 
regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromocenter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromocenter ISO
Inferred from Sequence Orthology
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
midbody ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
methyl-CpG-binding domain protein 5
Names
methyl-CpG-binding protein MBD5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290656.1NP_001277585.1  methyl-CpG-binding domain protein 5 isoform b

    See identical proteins and their annotated locations for NP_001277585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. The 5' UTR of this variant is incomplete due to a lack of full-length transcript support and splice pattern ambiguity in the upstream region.
    Source sequence(s)
    AL845298, AV298746, BQ551845, BU610422, BX546465, CB522230
    Consensus CDS
    CCDS71051.1
    UniProtKB/Swiss-Prot
    B1AYB6
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:13871464
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  2. NM_029924.2NP_084200.1  methyl-CpG-binding domain protein 5 isoform a

    See identical proteins and their annotated locations for NP_084200.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). This variant has an inferred 5' UTR exon combination based on the mRNA AK155574.1.
    Source sequence(s)
    AK173176, AL845298, AL845521
    Consensus CDS
    CCDS38122.1
    UniProtKB/TrEMBL
    B1AYB5, Q69ZJ2
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    48949490..49319690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314914.1XP_017170403.1  methyl-CpG-binding domain protein 5 isoform X2

    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171656
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  2. XM_017314915.1XP_017170404.1  methyl-CpG-binding domain protein 5 isoform X4

    UniProtKB/Swiss-Prot
    B1AYB6
    Related
    ENSMUSP00000108374.1, ENSMUST00000112754.7
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:13871464
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  3. XM_017314916.1XP_017170405.1  methyl-CpG-binding domain protein 5 isoform X5

    Related
    ENSMUSP00000119317.1, ENSMUST00000122841.7
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:12541293
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  4. XM_017314910.1XP_017170399.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  5. XM_017314909.1XP_017170398.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  6. XM_017314911.1XP_017170400.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  7. XM_017314912.1XP_017170401.1  methyl-CpG-binding domain protein 5 isoform X1

    UniProtKB/TrEMBL
    B1AYB5
    Related
    ENSMUSP00000036847.3, ENSMUST00000047413.9
    Conserved Domains (2) summary
    cl00110
    Location:2179
    MBD; MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to ...
    cl02554
    Location:16171694
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...
  8. XM_006497604.2XP_006497667.1  methyl-CpG-binding domain protein 5 isoform X3

    Conserved Domains (1) summary
    cl02554
    Location:14981575
    PWWP; The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins ...

RNA

  1. XR_001780404.1 RNA Sequence

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