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YIF1A Yip1 interacting factor homolog A, membrane trafficking protein [ Homo sapiens (human) ]

Gene ID: 10897, updated on 22-Aug-2020

Summary

Official Symbol
YIF1Aprovided by HGNC
Official Full Name
Yip1 interacting factor homolog A, membrane trafficking proteinprovided by HGNC
Primary source
HGNC:HGNC:16688
See related
Ensembl:ENSG00000174851 MIM:611484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
54TM; YIF1; YIF1P; FinGER7
Expression
Ubiquitous expression in duodenum (RPKM 11.2), liver (RPKM 9.6) and 25 other tissues See more
Orthologs

Genomic context

See YIF1A in Genome Data Viewer
Location:
11q13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (66284580..66289143, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66052051..66056638, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RAB1B, member RAS oncogene family Neighboring gene uncharacterized LOC107984340 Neighboring gene cornichon family AMPA receptor auxiliary protein 2 Neighboring gene Sharpr-MPRA regulatory region 5915 Neighboring gene transmembrane protein 151A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein YIF1A
Names
54TMp
YIP1-interacting factor homolog A
Yip1p-interacting factor
putative Rab5-interacting protein
putative transmembrane protein 54TMp

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300861.2NP_001287790.1  protein YIF1A isoform 2

    See identical proteins and their annotated locations for NP_001287790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK226003, BG397210, DB085949
    Consensus CDS
    CCDS73325.1
    UniProtKB/TrEMBL
    A6NGW1
    Related
    ENSP00000352437.6, ENST00000359461.10
    Conserved Domains (1) summary
    pfam03878
    Location:57235
    YIF1; YIF1
  2. NM_020470.3NP_065203.2  protein YIF1A isoform 1

    See identical proteins and their annotated locations for NP_065203.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK291124, BC001299, BC009892
    Consensus CDS
    CCDS8132.1
    UniProtKB/Swiss-Prot
    O95070
    UniProtKB/TrEMBL
    A8K509
    Related
    ENSP00000366098.4, ENST00000376901.9
    Conserved Domains (1) summary
    pfam03878
    Location:57287
    YIF1; YIF1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    66284580..66289143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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