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Miga2 mitoguardin 2 [ Mus musculus (house mouse) ]

Gene ID: 108958, updated on 26-Sep-2022

Summary

Official Symbol
Miga2provided by MGI
Official Full Name
mitoguardin 2provided by MGI
Primary source
MGI:MGI:1922035
See related
Ensembl:ENSMUSG00000026858 AllianceGenome:MGI:1922035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam73b; C9orf54; 5730472N09Rik
Summary
Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Acts upstream of or within bone development. Predicted to be integral component of plasma membrane. Orthologous to human MIGA2 (mitoguardin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 26.5), mammary gland adult (RPKM 21.5) and 28 other tissues See more
Orthologs
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Genomic context

See Miga2 in Genome Data Viewer
Location:
2; 2 B
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30254232..30275532)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30364233..30385520)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nucleoporin 188 Neighboring gene predicted gene, 39780 Neighboring gene SH3-domain GRB2-like endophilin B2 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase Neighboring gene protein phosphatase 2 protein activator

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitoguardin 2
Names
family with sequence similarity 73, member B
mFLJ00199 protein
ortholog of family with sequence similarity 73, member B FAM73B
protein FAM73B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242407.2NP_001229336.1  mitoguardin 2 isoform 1

    See identical proteins and their annotated locations for NP_001229336.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL954388
    Consensus CDS
    CCDS15880.1
    UniProtKB/Swiss-Prot
    Q3UST7, Q8BK03
    Related
    ENSMUSP00000077127.8, ENSMUST00000077977.14
    Conserved Domains (1) summary
    pfam10265
    Location:31568
    DUF2217; Uncharacterized conserved protein (DUF2217)
  2. NM_001378906.1NP_001365835.1  mitoguardin 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Conserved Domains (1) summary
    pfam10265
    Location:31529
    Miga; Mitoguardin
  3. NM_001378907.1NP_001365836.1  mitoguardin 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Conserved Domains (1) summary
    pfam10265
    Location:31529
    Miga; Mitoguardin
  4. NM_001378909.1NP_001365838.1  mitoguardin 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Conserved Domains (1) summary
    pfam10265
    Location:30377
    Miga; Mitoguardin
  5. NM_001378911.1NP_001365840.1  mitoguardin 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL954388
    Conserved Domains (1) summary
    pfam10265
    Location:30377
    Miga; Mitoguardin
  6. NM_001407284.1NP_001394213.1  mitoguardin 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL954388
  7. NM_175392.3NP_780601.1  mitoguardin 2 isoform 1

    See identical proteins and their annotated locations for NP_780601.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC051404
    Consensus CDS
    CCDS15880.1
    UniProtKB/Swiss-Prot
    Q3UST7, Q8BK03
    Related
    ENSMUSP00000097787.4, ENSMUST00000100214.10
    Conserved Domains (1) summary
    pfam10265
    Location:31568
    DUF2217; Uncharacterized conserved protein (DUF2217)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30254232..30275532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497593.3XP_006497656.1  mitoguardin 2 isoform X1

    Conserved Domains (1) summary
    pfam10265
    Location:117654
    Miga; Mitoguardin
  2. XM_006497594.2XP_006497657.1  mitoguardin 2 isoform X2

    Conserved Domains (1) summary
    pfam10265
    Location:117615
    Miga; Mitoguardin
  3. XM_030246575.1XP_030102435.1  mitoguardin 2 isoform X3

    Conserved Domains (1) summary
    pfam10265
    Location:30377
    Miga; Mitoguardin

RNA

  1. XR_003949993.2 RNA Sequence

  2. XR_003949994.2 RNA Sequence

  3. XR_866005.2 RNA Sequence

  4. XR_003949995.1 RNA Sequence