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Rcc2 regulator of chromosome condensation 2 [ Mus musculus (house mouse) ]

Gene ID: 108911, updated on 26-Sep-2022

Summary

Official Symbol
Rcc2provided by MGI
Official Full Name
regulator of chromosome condensation 2provided by MGI
Primary source
MGI:MGI:1919784
See related
Ensembl:ENSMUSG00000040945 AllianceGenome:MGI:1919784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Td60; mKIAA1470; 2610510H01Rik; 2610529N02Rik
Summary
Enables small GTPase binding activity. Involved in several processes, including negative regulation of cell-substrate adhesion; regulation of GTPase activity; and regulation of ruffle assembly. Located in early endosome membrane; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human RCC2 (regulator of chromosome condensation 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 76.6), CNS E11.5 (RPKM 66.1) and 28 other tissues See more
Orthologs
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Genomic context

See Rcc2 in Genome Data Viewer
Location:
4; 4 D3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140427308..140450531)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (140701473..140723220)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor (GEF) 10-like Neighboring gene predicted gene, 42335 Neighboring gene predicted gene 13025 Neighboring gene peptidyl arginine deiminase, type VI Neighboring gene peptidyl arginine deiminase, type IV

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome passenger complex localization to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ruffle assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of ruffle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric core domain ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle midzone ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173867.5NP_776292.1  protein RCC2

    See identical proteins and their annotated locations for NP_776292.1

    Status: VALIDATED

    Source sequence(s)
    AK076040, AL954710, BC060624, CA751510
    Consensus CDS
    CCDS18852.1
    UniProtKB/Swiss-Prot
    Q6ZPQ0, Q8BK67
    Related
    ENSMUSP00000038144.6, ENSMUST00000038893.6
    Conserved Domains (1) summary
    COG5184
    Location:129479
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    140427308..140450531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163571.1XP_036019464.1  protein RCC2 isoform X1

    UniProtKB/Swiss-Prot
    Q6ZPQ0
    Related
    ENSMUSP00000071163.3, ENSMUST00000071169.9
    Conserved Domains (1) summary
    COG5184
    Location:129479
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
  2. XM_006538471.4XP_006538534.1  protein RCC2 isoform X1

    See identical proteins and their annotated locations for XP_006538534.1

    UniProtKB/Swiss-Prot
    Q6ZPQ0, Q8BK67
    Conserved Domains (1) summary
    COG5184
    Location:129479
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]