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PROKR1 prokineticin receptor 1 [ Homo sapiens (human) ]

Gene ID: 10887, updated on 20-Dec-2019

Summary

Official Symbol
PROKR1provided by HGNC
Official Full Name
prokineticin receptor 1provided by HGNC
Primary source
HGNC:HGNC:4524
See related
Ensembl:ENSG00000169618 MIM:607122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAQ; PKR1; GPR73; PK-R1; GPR73a
Summary
This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]
Expression
Biased expression in fat (RPKM 1.4), adrenal (RPKM 0.7) and 2 other tissues See more
Orthologs

Genomic context

See PROKR1 in Genome Data Viewer
Location:
2p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (68643579..68658251)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68870712..68883244)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aprataxin and PNKP like factor Neighboring gene nuclear pore associated protein 1 like pseudogene Neighboring gene transmembrane and coiled-coil domain family 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5025 Neighboring gene Rho GTPase activating protein 25 Neighboring gene uncharacterized LOC105374790

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Potential readthrough

Included gene: APLF

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prokineticin receptor 1
Names
G protein-coupled receptor 73
G protein-coupled receptor ZAQ

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051312.1 RefSeqGene

    Range
    5001..16989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138964.4NP_620414.1  prokineticin receptor 1

    See identical proteins and their annotated locations for NP_620414.1

    Status: REVIEWED

    Source sequence(s)
    AC105054
    Consensus CDS
    CCDS1889.1
    UniProtKB/Swiss-Prot
    Q8TCW9
    Related
    ENSP00000303775.3, ENST00000303786.4
    Conserved Domains (1) summary
    cd15204
    Location:63353
    7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    68643579..68658251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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