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MRPS30 mitochondrial ribosomal protein S30 [ Homo sapiens (human) ]

Gene ID: 10884, updated on 31-Jul-2021


Official Symbol
MRPS30provided by HGNC
Official Full Name
mitochondrial ribosomal protein S30provided by HGNC
Primary source
See related
Ensembl:ENSG00000112996 MIM:611991
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP; PDCD9; S30mt; MRP-S30
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. [provided by RefSeq, Jul 2008]
Ubiquitous expression in bone marrow (RPKM 11.2), kidney (RPKM 11.2) and 25 other tissues See more
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Genomic context

See MRPS30 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (44808947..44815514)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (44809049..44815616)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 383, pseudogene Neighboring gene MRPS30 divergent transcript Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 1 Neighboring gene embigin

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
A combined analysis of genome-wide association studies in breast cancer.
GeneReviews: Not available

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • DKFZp566B2024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in apoptotic process TAS
Traceable Author Statement
more info
involved_in translation IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
located_in mitochondrion IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
39S ribosomal protein S30, mitochondrial
28S ribosomal protein S30, mitochondrial
mitochondrial large ribosomal subunit protein mL65
mitochondrial large ribosomal subunit protein mS30
programmed cell death 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016640.4NP_057724.2  39S ribosomal protein S30, mitochondrial

    See identical proteins and their annotated locations for NP_057724.2

    Status: REVIEWED

    Source sequence(s)
    AF146192, BC007735, BU676154
    Consensus CDS
    ENSP00000424328.1, ENST00000507110.6
    Conserved Domains (1) summary
    PDCD9; Mitochondrial 28S ribosomal protein S30 (PDCD9)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)
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