Format

Send to:

Choose Destination

EDDM3A epididymal protein 3A [ Homo sapiens (human) ]

Gene ID: 10876, updated on 11-Jun-2021

Summary

Official Symbol
EDDM3Aprovided by HGNC
Official Full Name
epididymal protein 3Aprovided by HGNC
Primary source
HGNC:HGNC:16978
See related
Ensembl:ENSG00000181562 MIM:611580
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EP3A; HE3A; RAM1; FAM12A; HE3ALPHA; HE3-ALPHA
Summary
Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See EDDM3A in Genome Data Viewer
Location:
14q11.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (20722391..20748380)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21214046..21216539)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tRNA-Pro (anticodon TGG) 3-2 Neighboring gene ribonuclease A family member 4 Neighboring gene angiogenin Neighboring gene uncharacterized LOC107984671 Neighboring gene RAN binding protein 20 pseudogene Neighboring gene epididymal protein 3D, pseudogene Neighboring gene epididymal protein 3B Neighboring gene ribonuclease A family member k6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119614, MGC119615

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in sperm displacement TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
epididymal secretory protein E3-alpha
Names
epididymis secretory sperm binding protein
epididymis-specific 3 alpha
family with sequence similarity 12, member A
human epididymis-specific 3 alpha
human epididymis-specific protein 3-alpha
ribonuclease A M1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006683.5NP_006674.2  epididymal secretory protein E3-alpha precursor

    See identical proteins and their annotated locations for NP_006674.2

    Status: VALIDATED

    Source sequence(s)
    AL163636, BC096698, X76383
    Consensus CDS
    CCDS9556.1
    UniProtKB/Swiss-Prot
    Q14507
    UniProtKB/TrEMBL
    W0UTC5
    Related
    ENSP00000315098.2, ENST00000326842.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    20722391..20748380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020934.2XP_016876423.1  epididymal secretory protein E3-alpha isoform X1

    UniProtKB/Swiss-Prot
    Q14507
    UniProtKB/TrEMBL
    W0UTC5
Support Center