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SPINT3 serine peptidase inhibitor, Kunitz type 3 [ Homo sapiens (human) ]

Gene ID: 10816, updated on 5-Aug-2022

Summary

Official Symbol
SPINT3provided by HGNC
Official Full Name
serine peptidase inhibitor, Kunitz type 3provided by HGNC
Primary source
HGNC:HGNC:11248
See related
Ensembl:ENSG00000101446 MIM:613941; AllianceGenome:HGNC:11248
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HKIB9
Summary
Predicted to enable receptor antagonist activity and transforming growth factor beta binding activity. Predicted to be involved in negative regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See SPINT3 in Genome Data Viewer
Location:
20q13.12
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45512461..45515622, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47248342..47251497, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44141101..44144262, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 2 Neighboring gene uncharacterized LOC107987282 Neighboring gene ribosomal protein L5 pseudogene 2 Neighboring gene EPPIN-WFDC6 readthrough Neighboring gene WAP four-disulfide core domain 6 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 21

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables transforming growth factor beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kunitz-type protease inhibitor 3
Names
serine protease inhibitor, Kunitz type, 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006652.2NP_006643.1  kunitz-type protease inhibitor 3 precursor

    See identical proteins and their annotated locations for NP_006643.1

    Status: VALIDATED

    Source sequence(s)
    AL031663, AY372172, BX088813
    Consensus CDS
    CCDS46608.1
    UniProtKB/Swiss-Prot
    P49223, Q96KK2
    Related
    ENSP00000217428.6, ENST00000217428.7
    Conserved Domains (1) summary
    cd00109
    Location:3487
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    45512461..45515622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    47248342..47251497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)