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Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif 6 [ Mus musculus (house mouse) ]

Gene ID: 108154, updated on 12-May-2024

Summary

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Official Symbol
Adamts6provided by MGI
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 6provided by MGI
Primary source
MGI:MGI:1347348
See related
Ensembl:ENSMUSG00000046169 AllianceGenome:MGI:1347348
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADAM-TS6; b2b2029Clo; b2b2182Clo; b2b2228Clo; b2b1879.1Clo; b2b2187.1Clo; A930019D11Rik
Summary
Predicted to enable metalloendopeptidase activity. Acts upstream of or within circulatory system development and kidney development. Predicted to be active in extracellular matrix. Is expressed in embryo. Orthologous to human ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 4.5), bladder adult (RPKM 3.5) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Adamts6 in Genome Data Viewer
Location:
13 D1; 13 56.42 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (104423026..104633203)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104286518..104496695)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4090 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E9887 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:105076891-105077195 Neighboring gene centromere protein K Neighboring gene STARR-seq mESC enhancer starr_35536 Neighboring gene STARR-seq mESC enhancer starr_35537 Neighboring gene predicted gene 8680 Neighboring gene STARR-seq mESC enhancer starr_35538 Neighboring gene STARR-seq mESC enhancer starr_35540 Neighboring gene predicted gene, 53810 Neighboring gene CWC27 spliceosome-associated protein Neighboring gene STARR-positive B cell enhancer mm9_chr13:105580054-105580355 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:105607138-105607403 Neighboring gene STARR-seq mESC enhancer starr_35542 Neighboring gene splicing regulatory glutamine/lysine-rich protein 1interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure. Cao M, et al. Invest Ophthalmol Vis Sci, 2018 Mar 1. PMID 29625437
  2. Murine model indicates 22q11.2 signaling adaptor CRKL is a dosage-sensitive regulator of genitourinary development. Haller M, et al. Proc Natl Acad Sci U S A, 2017 May 9. PMID 28439006, Free PMC Article
  3. Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development. Mead TJ, et al. Elife, 2022 May 3. PMID 35503090, Free PMC Article
  4. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. Hurskainen TL, et al. J Biol Chem, 1999 Sep 3. PMID 10464288
  5. Genetic link between renal birth defects and congenital heart disease. San Agustin JT, et al. Nat Commun, 2016 Mar 22. PMID 27002738, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (9) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 6
Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081020.2 → NP_001074489.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 precursor

    See identical proteins and their annotated locations for NP_001074489.1

    Status: VALIDATED

    Source sequence(s)
    AC154830, AK030315, AK034499, AK044528
    Consensus CDS
    CCDS36773.1
    UniProtKB/TrEMBL
    D3Z1A5
    Related
    ENSMUSP00000064570.7, ENSMUST00000065766.7
    Conserved Domains (6) summary
    smart00209
    Location:561 → 613
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:250 → 465
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:43 → 191
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:719 → 829
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1083 → 1115
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:480 → 548
    ADAM_CR_2; ADAM cysteine-rich domain

RNA

  1. NR_136938.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154830, AC165950, AK030315, AK034499, AK044528
    Related
    ENSMUST00000224784.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    104423026..104633203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517516.2 → XP_006517579.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

    Conserved Domains (6) summary
    smart00209
    Location:182 → 234
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:340 → 450
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:704 → 736
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:101 → 169
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:465 → 520
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cl00064
    Location:1 → 86
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

  2. XM_036157826.1 → XP_036013719.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X3

    Conserved Domains (6) summary
    smart00209
    Location:182 → 234
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:258 → 364
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:618 → 650
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:101 → 169
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:379 → 434
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cl00064
    Location:1 → 86
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

  3. XM_030247122.1 → XP_030102982.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X4

    Conserved Domains (4) summary
    smart00209
    Location:71 → 123
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:229 → 339
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:593 → 625
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:10 → 58
    ADAM_CR_2; ADAM cysteine-rich domain

  4. XM_036157825.1 → XP_036013718.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X2

    Conserved Domains (6) summary
    smart00209
    Location:151 → 203
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:309 → 419
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:673 → 705
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:70 → 138
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:434 → 489
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cl00064
    Location:1 → 55
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

  5. XM_011244611.3 → XP_011242913.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X5

    See identical proteins and their annotated locations for XP_011242913.1

    UniProtKB/TrEMBL
    D3Z1A5
    Conserved Domains (6) summary
    smart00209
    Location:561 → 613
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:250 → 465
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:43 → 191
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:719 → 829
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1083 → 1115
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:480 → 548
    ADAM_CR_2; ADAM cysteine-rich domain

  6. XM_030247120.1 → XP_030102980.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

    Conserved Domains (6) summary
    smart00209
    Location:182 → 234
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:340 → 450
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:704 → 736
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:101 → 169
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:465 → 520
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cl00064
    Location:1 → 86
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

  7. XM_036157824.1 → XP_036013717.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

    Conserved Domains (6) summary
    smart00209
    Location:182 → 234
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:340 → 450
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:704 → 736
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:101 → 169
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:465 → 520
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cl00064
    Location:1 → 86
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

  8. XM_030247121.2 → XP_030102981.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1

    Conserved Domains (6) summary
    smart00209
    Location:182 → 234
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:340 → 450
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:704 → 736
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:101 → 169
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:465 → 520
    TSP1_ADAMTS; Thrombospondin type 1 domain
    cl00064
    Location:1 → 86
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

  9. XM_006517517.3 → XP_006517580.1  A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X4

    Conserved Domains (4) summary
    smart00209
    Location:71 → 123
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:229 → 339
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:593 → 625
    PLAC; PLAC (protease and lacunin) domain
    pfam17771
    Location:10 → 58
    ADAM_CR_2; ADAM cysteine-rich domain

RNA

  1. XR_003950407.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175496.2: Suppressed sequence

    Description
    NM_175496.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version

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