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Babam2 BRISC and BRCA1 A complex member 2 [ Mus musculus (house mouse) ]

Gene ID: 107976, updated on 5-Mar-2024

Summary

Official Symbol
Babam2provided by MGI
Official Full Name
BRISC and BRCA1 A complex member 2provided by MGI
Primary source
MGI:MGI:1333875
See related
Ensembl:ENSMUSG00000052139 AllianceGenome:MGI:1333875
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bre; 6030405P19Rik; B830038C02Rik
Summary
Enables tumor necrosis factor receptor binding activity. Predicted to be involved in several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of DNA repair; and response to ionizing radiation. Predicted to act upstream of or within several processes, including DNA repair; apoptotic process; and chromatin organization. Predicted to be located in cytosol and nucleus. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Is expressed in central nervous system and retina. Orthologous to human BABAM2 (BRISC and BRCA1 A complex member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 28.8), bladder adult (RPKM 19.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
5 B1; 5 17.27 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31855394..32242083)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (31697978..32084950)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4750 Neighboring gene STARR-seq mESC enhancer starr_12780 Neighboring gene STARR-seq mESC enhancer starr_12781 Neighboring gene predicted gene, 38424 Neighboring gene mitochondrial ribosomal protein L33 Neighboring gene ribokinase Neighboring gene microRNA 3473e Neighboring gene STARR-positive B cell enhancer ABC_E11723 Neighboring gene STARR-seq mESC enhancer starr_12782 Neighboring gene STARR-seq mESC enhancer starr_12783 Neighboring gene STARR-seq mESC enhancer starr_12784 Neighboring gene STARR-positive B cell enhancer mm9_chr5:32316174-32316475 Neighboring gene predicted gene, 52770 Neighboring gene STARR-seq mESC enhancer starr_12785 Neighboring gene microRNA 12198 Neighboring gene predicted gene, 40277 Neighboring gene predicted gene, 36665

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic G2/M transition checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA damage checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of BRCA1-A complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of BRCA1-A complex ISO
Inferred from Sequence Orthology
more info
 
part_of BRCA1-A complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of BRISC complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
BRISC and BRCA1-A complex member 2
Names
BRCA1-A complex subunit BRE
BRCA1/BRCA2-containing complex subunit 45
brain and reproductive organ-expressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144541.1NP_653124.1  BRISC and BRCA1-A complex member 2 isoform V

    See identical proteins and their annotated locations for NP_653124.1

    Status: PROVISIONAL

    Source sequence(s)
    AF440752
    Consensus CDS
    CCDS19188.1
    UniProtKB/Swiss-Prot
    Q497G6, Q6P8Z2, Q8BKU1, Q8CJ13, Q8JZP0, Q8K3V9, Q8K3W0, Q8VHN1
    UniProtKB/TrEMBL
    D3Z7P0
    Related
    ENSMUSP00000144205.2, ENSMUST00000201352.4
    Conserved Domains (1) summary
    pfam06113
    Location:8333
    BRE; Brain and reproductive organ-expressed protein (BRE)
  2. NM_181279.1NP_851796.1  BRISC and BRCA1-A complex member 2 isoform I

    See identical proteins and their annotated locations for NP_851796.1

    Status: PROVISIONAL

    Source sequence(s)
    AF527952
    Consensus CDS
    CCDS19189.1
    UniProtKB/TrEMBL
    D3Z7P0
    Related
    ENSMUSP00000069133.5, ENSMUST00000063813.11
    Conserved Domains (1) summary
    pfam06113
    Location:8370
    BRE; Brain and reproductive organ-expressed protein (BRE)
  3. NM_181280.1NP_851797.1  BRISC and BRCA1-A complex member 2 isoform IV

    See identical proteins and their annotated locations for NP_851797.1

    Status: PROVISIONAL

    Source sequence(s)
    AF538925
    Consensus CDS
    CCDS39058.1
    UniProtKB/TrEMBL
    D3Z7P0
    Related
    ENSMUSP00000071462.6, ENSMUST00000071531.12
    Conserved Domains (1) summary
    pfam06113
    Location:32324
    BRE; Brain and reproductive organ-expressed protein (BRE)
  4. NM_181281.1NP_851798.1  BRISC and BRCA1-A complex member 2 isoform III

    See identical proteins and their annotated locations for NP_851798.1

    Status: PROVISIONAL

    Source sequence(s)
    AF527955
    Consensus CDS
    CCDS51461.1
    UniProtKB/Swiss-Prot
    Q8K3W0
    Related
    ENSMUSP00000110152.4, ENSMUST00000114507.10
    Conserved Domains (1) summary
    pfam06113
    Location:6269
    BRE; Brain and reproductive organ-expressed protein (BRE)
  5. NM_181282.1NP_851799.1  BRISC and BRCA1-A complex member 2 isoform II

    See identical proteins and their annotated locations for NP_851799.1

    Status: PROVISIONAL

    Source sequence(s)
    AF527953
    Consensus CDS
    CCDS39059.1
    UniProtKB/Swiss-Prot
    Q8K3W0
    Related
    ENSMUSP00000128351.2, ENSMUST00000131995.7
    Conserved Domains (1) summary
    pfam06113
    Location:1195
    BRE; Brain and reproductive organ-expressed protein (BRE)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31855394..32242083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)