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KLRA1P killer cell lectin like receptor A1, pseudogene [ Homo sapiens (human) ]

Gene ID: 10748, updated on 5-Sep-2025
Official Symbol
KLRA1Pprovided by HGNC
Official Full Name
killer cell lectin like receptor A1, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:6372
See related
MIM:604274; AllianceGenome:HGNC:6372
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ly49; KLRA1; LY49L; KLRAP1; Ly-49L
Annotation information
Note: This locus was originally considered to be protein coding, but has been reclassified as a transcribed pseudogene because all associated transcripts are candidates for nonsense-mediated decay (NMD). PMID: 10369937 and 16492762 also state that this locus is likely to be a pseudogene. [13 Feb 2013]
Expression
Ubiquitous expression in skin (RPKM 2.9), lymph node (RPKM 2.6) and 23 other tissues See more
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See KLRA1P in Genome Data Viewer
Location:
12p13.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10588478..10599835, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10461894..10473161, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10741077..10752434, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SLC25A39 pseudogene 2 Neighboring gene long intergenic non-protein coding RNA 2446 Neighboring gene uncharacterized LOC105376675 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:10724334-10724939 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:10733376-10734575 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:10765265-10766144 and GRCh37_chr12:10766145-10767022 Neighboring gene mago homolog B, exon junction complex subunit Neighboring gene serine/threonine/tyrosine kinase 1 Neighboring gene Y-box binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4238 Neighboring gene uncharacterized LOC124902876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4240

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Identification of a human member of the Ly-49 multigene family. Westgaard IH, et al. Eur J Immunol, 1998 Jun. PMID 9645365
  2. Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint. Merck E, et al. J Immunol, 2011 Jul 1. PMID 21632721
  3. The human Ly-49L gene. Barten R, et al. Immunogenetics, 1999 Jul. PMID 10369937
  4. Heterogeneous but conserved natural killer receptor gene complexes in four major orders of mammals. Hao L, et al. Proc Natl Acad Sci U S A, 2006 Feb 28. PMID 16492762, Free PMC Article
  5. Comparative genomics of natural killer cell receptor gene clusters. Kelley J, et al. PLoS Genet, 2005 Aug. PMID 16132082, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells.
    Title: Ly49 family receptors are required for cancer immunosurveillance mediated by natural killer cells.
  2. Thymic cellularity is greatly reduced in LY49D transgenic mice due to an impaired transition from double-negative to double-positive stages (the pre-T cell receptor checkpoint).
    Title: Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint.
  3. Natural killer (NK) cell licensing through Ly49 involves specific interactions with its transgenic histocompatibility complex (self-MHC) ligand that are similar to those involved in effector inhibition.
    Title: Ly49-dependent NK cell licensing and effector inhibition involve the same interaction site on MHC ligands.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  6. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes.
  7. biochemical analysis of the major histocompatibility complex class I-binding site of Ly49 natural killer cell receptors
    Title: Molecular architecture of the major histocompatibility complex class I-binding site of Ly49 natural killer cell receptors.
Submit: New GeneRIF Correction

Review eQTL and phenotype association data in this region using PheGenI

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Other Names

  • killer cell lectin-like receptor subfamily A pseudogene 1
  • killer cell lectin-like receptor subfamily A, member 1, pseudogene

Clone Names

  • MGC126520, MGC126522

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_028045.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC021049, BC069672, BC069697, BX950927, CN269037, DA776936

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    10588478..10599835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    10461894..10473161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_006611.2: Suppressed sequence

    Description
    NM_006611.2: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.
Nucleotide Protein
Heading Accession and Version

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