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Acaca acetyl-Coenzyme A carboxylase alpha [ Mus musculus (house mouse) ]

Gene ID: 107476, updated on 12-May-2024

Summary

Official Symbol
Acacaprovided by MGI
Official Full Name
acetyl-Coenzyme A carboxylase alphaprovided by MGI
Primary source
MGI:MGI:108451
See related
Ensembl:ENSMUSG00000020532 AllianceGenome:MGI:108451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acac; Acc1; Gm738; A530025K05Rik
Summary
Enables acetyl-CoA carboxylase activity. Involved in acetyl-CoA metabolic process; fatty acid biosynthetic process; and protein homotetramerization. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; lipid homeostasis; and tissue homeostasis. Located in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 81.6), subcutaneous fat pad adult (RPKM 79.2) and 17 other tissues See more
Orthologs
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Genomic context

See Acaca in Genome Data Viewer
Location:
11 C; 11 51.29 cM
Exon count:
60
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84020461..84292477)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84129635..84401651)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11769 Neighboring gene synergin, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:83845520-83845821 Neighboring gene STARR-seq mESC enhancer starr_30212 Neighboring gene dual specificity phosphatase 14 Neighboring gene transcriptional adaptor 2A Neighboring gene predicted gene 11437 Neighboring gene 60S ribosomal protein L35 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30214 Neighboring gene STARR-positive B cell enhancer mm9_chr11:84077985-84078286 Neighboring gene STARR-seq mESC enhancer starr_30216 Neighboring gene STARR-seq mESC enhancer starr_30218 Neighboring gene STARR-seq mESC enhancer starr_30219 Neighboring gene apoptosis antagonizing transcription factor Neighboring gene STARR-seq mESC enhancer starr_30220 Neighboring gene LIM homeobox protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables acetyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetyl-CoA carboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acetyl-CoA carboxylase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables acetyl-CoA carboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables acetyl-CoA carboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables biotin binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to prostaglandin E stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
acetyl-CoA carboxylase 1
Names
ACC-alpha
acetyl-CoA carboxylase 265
NP_579938.2
XP_006532016.1
XP_006532017.1
XP_006532018.1
XP_006532019.1
XP_011246968.2
XP_011246969.1
XP_030101321.1
XP_030101322.1
XP_030101323.1
XP_036012108.1
XP_036012109.1
XP_036012110.1
XP_036012111.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133360.3NP_579938.2  acetyl-CoA carboxylase 1

    See identical proteins and their annotated locations for NP_579938.2

    Status: VALIDATED

    Source sequence(s)
    AL596252, AL596447
    Consensus CDS
    CCDS25185.1
    UniProtKB/Swiss-Prot
    A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:16682216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:8191568
    ACC_central; Acetyl-CoA carboxylase, central region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    84020461..84292477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248667.2XP_011246969.1  acetyl-CoA carboxylase 1 isoform X4

    See identical proteins and their annotated locations for XP_011246969.1

    UniProtKB/Swiss-Prot
    A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:16682216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:8191568
    ACC_central; Acetyl-CoA carboxylase, central region
  2. XM_030245463.1XP_030101323.1  acetyl-CoA carboxylase 1 isoform X5

    Conserved Domains (5) summary
    COG0439
    Location:1450
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:501648
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:583648
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:14992047
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:6501399
    ACC_central; Acetyl-CoA carboxylase, central region
  3. XM_006531953.3XP_006532016.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5SWU9
    Conserved Domains (5) summary
    COG0439
    Location:155657
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:708855
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:791855
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:17062254
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:8571606
    ACC_central; Acetyl-CoA carboxylase, central region
  4. XM_036156216.1XP_036012109.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/Swiss-Prot
    A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:16682216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:8191568
    ACC_central; Acetyl-CoA carboxylase, central region
  5. XM_036156215.1XP_036012108.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/Swiss-Prot
    A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:16682216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:8191568
    ACC_central; Acetyl-CoA carboxylase, central region
  6. XM_006531954.3XP_006532017.1  acetyl-CoA carboxylase 1 isoform X4

    See identical proteins and their annotated locations for XP_006532017.1

    UniProtKB/Swiss-Prot
    A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
    Related
    ENSMUSP00000099490.2, ENSMUST00000103201.8
    Conserved Domains (5) summary
    COG0439
    Location:117619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:16682216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:8191568
    ACC_central; Acetyl-CoA carboxylase, central region
  7. XM_006531956.3XP_006532019.1  acetyl-CoA carboxylase 1 isoform X4

    See identical proteins and their annotated locations for XP_006532019.1

    UniProtKB/Swiss-Prot
    A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
    Related
    ENSMUSP00000020843.7, ENSMUST00000020843.13
    Conserved Domains (5) summary
    COG0439
    Location:117619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:16682216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:8191568
    ACC_central; Acetyl-CoA carboxylase, central region
  8. XM_036156217.1XP_036012110.1  acetyl-CoA carboxylase 1 isoform X5

    Conserved Domains (5) summary
    COG0439
    Location:1450
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:501648
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:583648
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:14992047
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:6501399
    ACC_central; Acetyl-CoA carboxylase, central region
  9. XM_030245461.2XP_030101321.1  acetyl-CoA carboxylase 1 isoform X1

    Conserved Domains (5) summary
    COG0439
    Location:195697
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:748895
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:831895
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:17462294
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:8971646
    ACC_central; Acetyl-CoA carboxylase, central region
  10. XM_011248666.3XP_011246968.2  acetyl-CoA carboxylase 1 isoform X2

    Conserved Domains (5) summary
    COG0439
    Location:195697
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:748895
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:831895
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:17382286
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:8971638
    ACC_central; Acetyl-CoA carboxylase, central region
  11. XM_006531955.3XP_006532018.1  acetyl-CoA carboxylase 1 isoform X4

    See identical proteins and their annotated locations for XP_006532018.1

    UniProtKB/Swiss-Prot
    A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:16682216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:8191568
    ACC_central; Acetyl-CoA carboxylase, central region
  12. XM_036156218.1XP_036012111.1  acetyl-CoA carboxylase 1 isoform X5

    Conserved Domains (5) summary
    COG0439
    Location:1450
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:501648
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:583648
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:14992047
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:6501399
    ACC_central; Acetyl-CoA carboxylase, central region
  13. XM_030245462.2XP_030101322.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/Swiss-Prot
    A2A6H4, Q5SWU6, Q5SWU7, Q5SWU8, Q5SWU9, Q6JIZ1, Q6PHL9, Q705X8, Q705X9, Q91VC8, Q925C4, Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:16682216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:8191568
    ACC_central; Acetyl-CoA carboxylase, central region