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Acaca acetyl-Coenzyme A carboxylase alpha [ Mus musculus (house mouse) ]

Gene ID: 107476, updated on 14-Mar-2023

Summary

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Official Symbol
Acacaprovided by MGI
Official Full Name
acetyl-Coenzyme A carboxylase alphaprovided by MGI
Primary source
MGI:MGI:108451
See related
Ensembl:ENSMUSG00000020532 AllianceGenome:MGI:108451
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acac; Acc1; Gm738; A530025K05Rik
Summary
Enables acetyl-CoA carboxylase activity. Involved in acetyl-CoA metabolic process; fatty acid biosynthetic process; and protein homotetramerization. Acts upstream of or within several processes, including cellular response to prostaglandin E stimulus; lipid homeostasis; and tissue homeostasis. Located in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 81.6), subcutaneous fat pad adult (RPKM 79.2) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Acaca in Genome Data Viewer
Location:
11; 11 C
Exon count:
60
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84020461..84292477)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84129635..84401651)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene synergin, gamma Neighboring gene dual specificity phosphatase 14 Neighboring gene transcriptional adaptor 2A Neighboring gene predicted gene 11437 Neighboring gene 60S ribosomal protein L35 pseudogene Neighboring gene apoptosis antagonizing transcription factor Neighboring gene LIM homeobox protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice. Nakajima T, et al. J Exp Med, 2021 Dec 6. PMID 34813654, Free PMC Article
  2. ACC1 determines memory potential of individual CD4(+) T cells by regulating de novo fatty acid biosynthesis. Endo Y, et al. Nat Metab, 2019 Feb. PMID 32694782
  3. ACC1 (Acetyl Coenzyme A Carboxylase 1) Is a Potential Immune Modulatory Target of Cerebral Ischemic Stroke. Wang X, et al. Stroke, 2019 Jul. PMID 31177975
  4. Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass. Cantley J, et al. Diabetologia, 2019 Jan. PMID 30334081, Free PMC Article
  5. Obesity Drives Th17 Cell Differentiation by Inducing the Lipid Metabolic Kinase, ACC1. Endo Y, et al. Cell Rep, 2015 Aug 11. PMID 26235623

See all (113) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.
    Title: Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion.
  2. ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.
    Title: ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.
  3. Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.
    Title: Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.
  4. ACC1 determines memory potential of individual CD4(+) T cells by regulating de novo fatty acid biosynthesis.
    Title: ACC1 determines memory potential of individual CD4(+) T cells by regulating de novo fatty acid biosynthesis.
  5. Inhibition of ACC1 can be a previously unrecognized mechanism that underlies calorie restriction-afforded neuroprotection against cerebral ischemic stroke
    Title: ACC1 (Acetyl Coenzyme A Carboxylase 1) Is a Potential Immune Modulatory Target of Cerebral Ischemic Stroke.
  6. Using mice with Ser(79)Ala/Ser(212)Ala knock-in mutations (ACC DKI) the authors find that inhibition of ACC phosphorylation leads to reduced appetite in response to fasting or cold exposure.
    Title: AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.
  7. AMPK-ACC signaling is coupled to the control of thrombosis by specifically modulating thromboxane and granule release in response to collagen.
    Title: AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.
  8. Lipogenesis is dispensable for liver tumorigenesis in mice treated with diethylnitrosamine, and ACC enzymes have an important role in redox regulation and cell survival.
    Title: Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.
  9. the present studies report for the first time a role of ACC1 in suppressing breast cancer migration and invasion by an fatty acid synthesis-independent, but acetyl-CoA-dependent, impact on the epithelial-mesenchymal transition programs in breast tumor cells and its subsequent importance for tumor invasion and recurrence.
    Title: Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence.
  10. of ACCs decreased polyunsaturated fatty acid (PUFA) concentrations in liver due to reduced malonyl-CoA, which is required for elongation of essential fatty acids.
    Title: Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (8)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables acetyl-CoA carboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetyl-CoA carboxylase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables acetyl-CoA carboxylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acetyl-CoA carboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables biotin binding ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to prostaglandin E stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
acetyl-CoA carboxylase 1
Names
ACC-alpha
acetyl-CoA carboxylase 265
NP_579938.2
XP_006532016.1
XP_006532017.1
XP_006532018.1
XP_006532019.1
XP_006532020.1
XP_011246968.2
XP_011246969.1
XP_030101321.1
XP_030101322.1
XP_030101323.1
XP_036012108.1
XP_036012109.1
XP_036012110.1
XP_036012111.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133360.3 → NP_579938.2  acetyl-CoA carboxylase 1

    See identical proteins and their annotated locations for NP_579938.2

    Status: VALIDATED

    Source sequence(s)
    AL596252, AL596447
    Consensus CDS
    CCDS25185.1
    UniProtKB/Swiss-Prot
    Q5SWU9, Q925C5
    Related
    ENSMUSP00000020843.7, ENSMUST00000020843.13
    Conserved Domains (5) summary
    COG0439
    Location:117 → 619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670 → 817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752 → 817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1668 → 2216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:819 → 1568
    ACC_central; Acetyl-CoA carboxylase, central region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    84020461..84292477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248667.2 → XP_011246969.1  acetyl-CoA carboxylase 1 isoform X4

    See identical proteins and their annotated locations for XP_011246969.1

    UniProtKB/Swiss-Prot
    Q5SWU9, Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117 → 619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670 → 817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752 → 817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1668 → 2216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:819 → 1568
    ACC_central; Acetyl-CoA carboxylase, central region

  2. XM_030245463.1 → XP_030101323.1  acetyl-CoA carboxylase 1 isoform X5

    Conserved Domains (5) summary
    COG0439
    Location:1 → 450
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:501 → 648
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:583 → 648
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1499 → 2047
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:650 → 1399
    ACC_central; Acetyl-CoA carboxylase, central region

  3. XM_006531953.3 → XP_006532016.1  acetyl-CoA carboxylase 1 isoform X3

    UniProtKB/Swiss-Prot
    Q5SWU9
    Conserved Domains (5) summary
    COG0439
    Location:155 → 657
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:708 → 855
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:791 → 855
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1706 → 2254
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:857 → 1606
    ACC_central; Acetyl-CoA carboxylase, central region

  4. XM_036156216.1 → XP_036012109.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117 → 619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670 → 817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752 → 817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1668 → 2216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:819 → 1568
    ACC_central; Acetyl-CoA carboxylase, central region

  5. XM_036156215.1 → XP_036012108.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117 → 619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670 → 817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752 → 817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1668 → 2216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:819 → 1568
    ACC_central; Acetyl-CoA carboxylase, central region

  6. XM_006531954.3 → XP_006532017.1  acetyl-CoA carboxylase 1 isoform X4

    See identical proteins and their annotated locations for XP_006532017.1

    UniProtKB/Swiss-Prot
    Q5SWU9, Q925C5
    Related
    ENSMUSP00000099490.2, ENSMUST00000103201.8
    Conserved Domains (5) summary
    COG0439
    Location:117 → 619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670 → 817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752 → 817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1668 → 2216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:819 → 1568
    ACC_central; Acetyl-CoA carboxylase, central region

  7. XM_006531956.3 → XP_006532019.1  acetyl-CoA carboxylase 1 isoform X4

    See identical proteins and their annotated locations for XP_006532019.1

    UniProtKB/Swiss-Prot
    Q5SWU9, Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117 → 619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670 → 817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752 → 817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1668 → 2216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:819 → 1568
    ACC_central; Acetyl-CoA carboxylase, central region

  8. XM_006531957.5 → XP_006532020.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q5SWU9
    Conserved Domains (5) summary
    COG0439
    Location:117 → 619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670 → 817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752 → 817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1668 → 2216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:819 → 1568
    ACC_central; Acetyl-CoA carboxylase, central region

  9. XM_036156217.1 → XP_036012110.1  acetyl-CoA carboxylase 1 isoform X5

    Conserved Domains (5) summary
    COG0439
    Location:1 → 450
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:501 → 648
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:583 → 648
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1499 → 2047
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:650 → 1399
    ACC_central; Acetyl-CoA carboxylase, central region

  10. XM_030245461.2 → XP_030101321.1  acetyl-CoA carboxylase 1 isoform X1

    Conserved Domains (5) summary
    COG0439
    Location:195 → 697
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:748 → 895
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:831 → 895
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1746 → 2294
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:897 → 1646
    ACC_central; Acetyl-CoA carboxylase, central region

  11. XM_011248666.3 → XP_011246968.2  acetyl-CoA carboxylase 1 isoform X2

    Conserved Domains (5) summary
    COG0439
    Location:195 → 697
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:748 → 895
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:831 → 895
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1738 → 2286
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:897 → 1638
    ACC_central; Acetyl-CoA carboxylase, central region

  12. XM_006531955.3 → XP_006532018.1  acetyl-CoA carboxylase 1 isoform X4

    See identical proteins and their annotated locations for XP_006532018.1

    UniProtKB/Swiss-Prot
    Q5SWU9, Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117 → 619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670 → 817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752 → 817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1668 → 2216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:819 → 1568
    ACC_central; Acetyl-CoA carboxylase, central region

  13. XM_036156218.1 → XP_036012111.1  acetyl-CoA carboxylase 1 isoform X5

    Conserved Domains (5) summary
    COG0439
    Location:1 → 450
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:501 → 648
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:583 → 648
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1499 → 2047
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:650 → 1399
    ACC_central; Acetyl-CoA carboxylase, central region

  14. XM_030245462.2 → XP_030101322.1  acetyl-CoA carboxylase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q925C5
    Conserved Domains (5) summary
    COG0439
    Location:117 → 619
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:670 → 817
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam00364
    Location:752 → 817
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1668 → 2216
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:819 → 1568
    ACC_central; Acetyl-CoA carboxylase, central region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SWU9.1 GenPept UniProtKB/Swiss-Prot:Q5SWU9

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