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RFPL2 ret finger protein like 2 [ Homo sapiens (human) ]

Gene ID: 10739, updated on 9-Oct-2021

Summary

Official Symbol
RFPL2provided by HGNC
Official Full Name
ret finger protein like 2provided by HGNC
Primary source
HGNC:HGNC:9979
See related
Ensembl:ENSG00000128253 MIM:605969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF79
Expression
Biased expression in prostate (RPKM 5.5) and brain (RPKM 0.5) See more
Orthologs
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Genomic context

See RFPL2 in Genome Data Viewer
Location:
22q12.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (32190435..32205073, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (32586422..32600836, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene AP1B1 pseudogene 2 Neighboring gene chromosome 22 open reading frame 42 Neighboring gene SLC5A4 antisense RNA 1 Neighboring gene solute carrier family 5 member 4 Neighboring gene CPSF1 pseudogene 1 Neighboring gene uncharacterized LOC107985561

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ret finger protein-like 2
Names
RING finger protein 79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098527.3NP_001091997.2  ret finger protein-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001091997.2

    Status: VALIDATED

    Source sequence(s)
    AK055999, BC069827, DB549304
    Consensus CDS
    CCDS43009.2
    UniProtKB/Swiss-Prot
    O75678
    Related
    ENSP00000383096.1, ENST00000400237.2
    Conserved Domains (4) summary
    cd15821
    Location:183360
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd00162
    Location:101142
    RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]
    pfam11002
    Location:144185
    RDM; RFPL defining motif (RDM)
    cl17238
    Location:100143
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. NM_001159545.3NP_001153017.1  ret finger protein-like 2 isoform 3

    See identical proteins and their annotated locations for NP_001153017.1

    Status: VALIDATED

    Source sequence(s)
    AL008723
    UniProtKB/Swiss-Prot
    O75678
    Conserved Domains (4) summary
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd00162
    Location:1152
    RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    cl17238
    Location:1053
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  3. NM_001159546.3NP_001153018.1  ret finger protein-like 2 isoform 3

    See identical proteins and their annotated locations for NP_001153018.1

    Status: VALIDATED

    Source sequence(s)
    AL008723
    UniProtKB/Swiss-Prot
    O75678
    Conserved Domains (4) summary
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd00162
    Location:1152
    RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    cl17238
    Location:1053
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  4. NM_001364982.2NP_001351911.1  ret finger protein-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL008723
    Conserved Domains (3) summary
    cd15821
    Location:115292
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    pfam11002
    Location:76117
    RDM; RFPL defining motif (RDM)
    cd16621
    Location:3275
    vRING-HC-C4C4_RFPL1_like; Variant RING finger, HC subclass (C4C4-type), found in Ret finger protein-like (RFPL) family
  5. NM_001364983.3NP_001351912.1  ret finger protein-like 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL008723
    Conserved Domains (3) summary
    cd15821
    Location:221398
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd16621
    Location:138181
    vRING-HC-C4C4_RFPL1_like; Variant RING finger, HC subclass (C4C4-type), found in Ret finger protein-like (RFPL) family
    pfam11002
    Location:182223
    RDM; RFPL defining motif (RDM)
  6. NM_001364984.3NP_001351913.1  ret finger protein-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL008723
    Conserved Domains (4) summary
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd00162
    Location:1152
    RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    cl17238
    Location:1053
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  7. NM_001364985.3NP_001351914.1  ret finger protein-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL008723
    Conserved Domains (4) summary
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd00162
    Location:1152
    RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    cl17238
    Location:1053
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  8. NM_001364986.3NP_001351915.1  ret finger protein-like 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL008723
    Conserved Domains (3) summary
    cd15821
    Location:221398
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd16621
    Location:138181
    vRING-HC-C4C4_RFPL1_like; Variant RING finger, HC subclass (C4C4-type), found in Ret finger protein-like (RFPL) family
    pfam11002
    Location:182223
    RDM; RFPL defining motif (RDM)
  9. NM_001394554.1NP_001381483.1  ret finger protein-like 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL008723
    Conserved Domains (3) summary
    cd15821
    Location:221398
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd16621
    Location:138181
    vRING-HC-C4C4_RFPL1_like; Variant RING finger, HC subclass (C4C4-type), found in Ret finger protein-like (RFPL) family
    pfam11002
    Location:182223
    RDM; RFPL defining motif (RDM)
  10. NM_001394555.1NP_001381484.1  ret finger protein-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL008723
    Conserved Domains (4) summary
    cd15821
    Location:183360
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd00162
    Location:101142
    RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]
    pfam11002
    Location:144185
    RDM; RFPL defining motif (RDM)
    cl17238
    Location:100143
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  11. NM_001394556.1NP_001381485.1  ret finger protein-like 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL008723
    Conserved Domains (3) summary
    cd15821
    Location:97274
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd00162
    Location:1556
    RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]
    cl17238
    Location:1457
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  12. NM_001394557.1NP_001381486.1  ret finger protein-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL008723
    Conserved Domains (4) summary
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd00162
    Location:1152
    RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    cl17238
    Location:1053
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  13. NM_001394558.1NP_001381487.1  ret finger protein-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL008723
    Conserved Domains (4) summary
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd00162
    Location:1152
    RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    cl17238
    Location:1053
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  14. NM_001394559.1NP_001381488.1  ret finger protein-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL008723
    Conserved Domains (4) summary
    cd15821
    Location:93270
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd00162
    Location:1152
    RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]
    pfam11002
    Location:5495
    RDM; RFPL defining motif (RDM)
    cl17238
    Location:1053
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    32190435..32205073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529832.2XP_011528134.1  ret finger protein-like 2 isoform X2

    See identical proteins and their annotated locations for XP_011528134.1

    UniProtKB/Swiss-Prot
    O75678
    Related
    ENSP00000248983.5, ENST00000248983.8
    Conserved Domains (4) summary
    cd15821
    Location:183360
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd00162
    Location:101142
    RING_Ubox; variant RING-HC finger (C4C4-type) [structural motif]
    pfam11002
    Location:144185
    RDM; RFPL defining motif (RDM)
    cl17238
    Location:100143
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_011529828.2XP_011528130.1  ret finger protein-like 2 isoform X1

    See identical proteins and their annotated locations for XP_011528130.1

    Conserved Domains (3) summary
    cd15821
    Location:221398
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd16621
    Location:138181
    vRING-HC-C4C4_RFPL1_like; Variant RING finger, HC subclass (C4C4-type), found in Ret finger protein-like (RFPL) family
    pfam11002
    Location:182223
    RDM; RFPL defining motif (RDM)
  3. XM_011529826.2XP_011528128.1  ret finger protein-like 2 isoform X1

    See identical proteins and their annotated locations for XP_011528128.1

    Conserved Domains (3) summary
    cd15821
    Location:221398
    SPRY_PRY_RFPL; Ret finger protein-like (RFPL), includes RFP1, 2, 3, 4
    cd16621
    Location:138181
    vRING-HC-C4C4_RFPL1_like; Variant RING finger, HC subclass (C4C4-type), found in Ret finger protein-like (RFPL) family
    pfam11002
    Location:182223
    RDM; RFPL defining motif (RDM)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_006605.3: Suppressed sequence

    Description
    NM_006605.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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