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Me2 malic enzyme 2, NAD(+)-dependent, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 107029, updated on 12-May-2024

Summary

Official Symbol
Me2provided by MGI
Official Full Name
malic enzyme 2, NAD(+)-dependent, mitochondrialprovided by MGI
Primary source
MGI:MGI:2147351
See related
Ensembl:ENSMUSG00000024556 AllianceGenome:MGI:2147351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NAD-ME; D030040L20Rik
Summary
Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process; pyruvate metabolic process; and regulation of NADP metabolic process. Located in mitochondrion. Is expressed in several structures, including central nervous system; integumental system; metanephros; sensory organ; and skeleton. Orthologous to human ME2 (malic enzyme 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 31.9), duodenum adult (RPKM 13.7) and 25 other tissues See more
Orthologs
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Genomic context

See Me2 in Genome Data Viewer
Location:
18 E2; 18 49.95 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (73898025..73949326, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (73764954..73815438, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene EGF-like domain 7 pseudogene Neighboring gene elaC ribonuclease Z 1 Neighboring gene STARR-positive B cell enhancer ABC_E11003 Neighboring gene STARR-seq mESC enhancer starr_44997 Neighboring gene predicted gene, 52346 Neighboring gene predicted gene, 32661 Neighboring gene maestro

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables malate dehydrogenase (decarboxylating) (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables malic enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pyruvate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of NADP metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent malic enzyme, mitochondrial
NP_663469.1
XP_006525559.1
XP_036016815.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145494.3NP_663469.1  NAD-dependent malic enzyme, mitochondrial precursor

    See identical proteins and their annotated locations for NP_663469.1

    Status: VALIDATED

    Source sequence(s)
    AC132418
    Consensus CDS
    CCDS29339.1
    UniProtKB/Swiss-Prot
    Q3TBM8, Q99KE1
    UniProtKB/TrEMBL
    Q3TSD4
    Related
    ENSMUSP00000025439.4, ENSMUST00000025439.5
    Conserved Domains (3) summary
    cd05312
    Location:280558
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:28566
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:89270
    malic; Malic enzyme, N-terminal domain

RNA

  1. NR_157387.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132418, AK077746

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    73898025..73949326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160922.1XP_036016815.1  NAD-dependent malic enzyme, mitochondrial isoform X2

    Conserved Domains (1) summary
    PLN03129
    Location:1390
    PLN03129; NADP-dependent malic enzyme; Provisional
  2. XM_006525496.4XP_006525559.1  NAD-dependent malic enzyme, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q3TSD4
    Conserved Domains (1) summary
    PLN03129
    Location:35573
    PLN03129; NADP-dependent malic enzyme; Provisional