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GMEB1 glucocorticoid modulatory element binding protein 1 [ Homo sapiens (human) ]

Gene ID: 10691, updated on 8-Dec-2018

Summary

Official Symbol
GMEB1provided by HGNC
Official Full Name
glucocorticoid modulatory element binding protein 1provided by HGNC
Primary source
HGNC:HGNC:4370
See related
Ensembl:ENSG00000162419 MIM:604409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIF96; P96PIF
Summary
This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 4.0), testis (RPKM 3.2) and 25 other tissues See more
Orthologs

Genomic context

See GMEB1 in Genome Data Viewer
Location:
1p35.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (28668728..28715603)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28995234..29042115)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAB42, member RAS oncogene family Neighboring gene TATA-box binding protein associated factor 12 Neighboring gene long intergenic non-protein coding RNA 1715 Neighboring gene RNA, U11 small nuclear Neighboring gene YTH N6-methyladenosine RNA binding protein 2 Neighboring gene opioid receptor delta 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glucocorticoid modulatory element-binding protein 1
Names
DNA-binding protein p96PIF
PIF p96
parvovirus initiation factor p96

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028983.1 RefSeqGene

    Range
    5001..51876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001319674.1NP_001306603.1  glucocorticoid modulatory element-binding protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AK000892, AK023126, DA647317
    Consensus CDS
    CCDS328.1
    UniProtKB/Swiss-Prot
    Q9Y692
    UniProtKB/TrEMBL
    B1AT47
    Related
    ENSP00000362922.1, ENST00000373816.5
    Conserved Domains (2) summary
    pfam01342
    Location:81155
    SAND; SAND domain
    cl25836
    Location:364452
    Retinal; Retinal protein
  2. NM_006582.3NP_006573.2  glucocorticoid modulatory element-binding protein 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK023126, AK315195, BC001473, DA647317, DA919003
    Consensus CDS
    CCDS327.1
    UniProtKB/Swiss-Prot
    Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
    Related
    ENSP00000294409.2, ENST00000294409.2
    Conserved Domains (2) summary
    pfam01342
    Location:91165
    SAND; SAND domain
    cl25836
    Location:374462
    Retinal; Retinal protein
  3. NM_024482.2NP_077808.1  glucocorticoid modulatory element-binding protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AK023126, BC001473, DA647317, DA919003
    Consensus CDS
    CCDS328.1
    UniProtKB/Swiss-Prot
    Q9Y692
    UniProtKB/TrEMBL
    B1AT47
    Related
    ENSP00000355186.4, ENST00000361872.8
    Conserved Domains (2) summary
    pfam01342
    Location:81155
    SAND; SAND domain
    cl25836
    Location:364452
    Retinal; Retinal protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    28668728..28715603
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540519.2XP_011538821.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y692
    Conserved Domains (2) summary
    pfam01342
    Location:91165
    SAND; SAND domain
    cl25836
    Location:374462
    Retinal; Retinal protein
  2. XM_011540522.3XP_011538824.1  glucocorticoid modulatory element-binding protein 1 isoform X3

    Conserved Domains (1) summary
    pfam15449
    Location:168256
    Retinal; Retinal protein
  3. XM_011540521.3XP_011538823.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9Y692
    UniProtKB/TrEMBL
    B1AT47
    Conserved Domains (2) summary
    pfam01342
    Location:81155
    SAND; SAND domain
    cl25836
    Location:364452
    Retinal; Retinal protein
  4. XM_017000087.1XP_016855576.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y692
    Conserved Domains (2) summary
    pfam01342
    Location:91165
    SAND; SAND domain
    cl25836
    Location:374462
    Retinal; Retinal protein
  5. XM_011540518.2XP_011538820.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y692
    Conserved Domains (2) summary
    pfam01342
    Location:91165
    SAND; SAND domain
    cl25836
    Location:374462
    Retinal; Retinal protein
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