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GMEB1 glucocorticoid modulatory element binding protein 1 [ Homo sapiens (human) ]

Gene ID: 10691, updated on 5-Jul-2025
Official Symbol
GMEB1provided by HGNC
Official Full Name
glucocorticoid modulatory element binding protein 1provided by HGNC
Primary source
HGNC:HGNC:4370
See related
Ensembl:ENSG00000162419 MIM:604409; AllianceGenome:HGNC:4370
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIF96; P96PIF
Summary
This gene encodes a member of KDWK gene family which associates with GMEB2 protein. The GMEB1-GMEB2 complex is essential for parvovirus DNA replication. Studies in rat for a similar gene suggest that this gene's role is to modulate the transactivation of the glucocorticoid receptor when it is bound to glucocorticoid response elements. Three alternative spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 4.0), testis (RPKM 3.2) and 25 other tissues See more
Orthologs
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See GMEB1 in Genome Data Viewer
Location:
1p35.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (28668229..28719353)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (28510195..28561345)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28995296..29045865)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28928951-28929451 Neighboring gene TATA-box binding protein associated factor 12 Neighboring gene Sharpr-MPRA regulatory region 12118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28971631-28972130 Neighboring gene TAF12 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 547 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28998036-28998554 Neighboring gene RNA, U11 small nuclear Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:29007753-29008252 Neighboring gene small Cajal body-specific RNA 24 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:29061369-29062268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 604 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:29063168-29064066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29069801-29070309 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:29074507-29074730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29075305-29075826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29075827-29076347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29081023-29081522 Neighboring gene YTH N6-methyladenosine RNA binding protein F2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:29089259-29089760 Neighboring gene Sharpr-MPRA regulatory region 15715 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 606 Neighboring gene NANOG hESC enhancer GRCh37_chr1:29133560-29134067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29141619-29142120 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:29161670-29162170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:29162171-29162671 Neighboring gene opioid receptor delta 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:29181461-29181962

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables Hsp27 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
glucocorticoid modulatory element-binding protein 1
Names
DNA-binding protein p96PIF
PIF p96
parvovirus initiation factor p96

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028983.2 RefSeqGene

    Range
    5557..56126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001319674.2NP_001306603.1  glucocorticoid modulatory element-binding protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AK000892, AK023126, AL645729
    Consensus CDS
    CCDS328.1
    UniProtKB/TrEMBL
    B1AT47, B2RCN8
    Related
    ENSP00000362922.1, ENST00000373816.6
    Conserved Domains (1) summary
    pfam01342
    Location:80155
    SAND; SAND domain
  2. NM_006582.4NP_006573.2  glucocorticoid modulatory element-binding protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006573.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK023126, AK315195, AL645729, BC001473
    Consensus CDS
    CCDS327.1
    UniProtKB/Swiss-Prot
    B1AT48, Q9NWH1, Q9UKD0, Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
    Related
    ENSP00000294409.2, ENST00000294409.2
    Conserved Domains (1) summary
    pfam01342
    Location:90165
    SAND; SAND domain
  3. NM_024482.3NP_077808.1  glucocorticoid modulatory element-binding protein 1 isoform 2

    See identical proteins and their annotated locations for NP_077808.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AK023126, AL645729, BC001473
    Consensus CDS
    CCDS328.1
    UniProtKB/TrEMBL
    B1AT47, B2RCN8
    Related
    ENSP00000355186.4, ENST00000361872.8
    Conserved Domains (1) summary
    pfam01342
    Location:80155
    SAND; SAND domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    28668229..28719353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438136.1XP_047294092.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B1AT48, Q9NWH1, Q9UKD0, Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
  2. XM_047438283.1XP_047294239.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B1AT47, B2RCN8
  3. XM_011540519.3XP_011538821.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011538821.1

    UniProtKB/Swiss-Prot
    B1AT48, Q9NWH1, Q9UKD0, Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
    Conserved Domains (1) summary
    pfam01342
    Location:90165
    SAND; SAND domain
  4. XM_047438187.1XP_047294143.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B1AT48, Q9NWH1, Q9UKD0, Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
  5. XM_017000087.2XP_016855576.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B1AT48, Q9NWH1, Q9UKD0, Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
    Conserved Domains (1) summary
    pfam01342
    Location:90165
    SAND; SAND domain
  6. XM_011540521.4XP_011538823.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011538823.1

    UniProtKB/TrEMBL
    B1AT47, B2RCN8
    Conserved Domains (1) summary
    pfam01342
    Location:80155
    SAND; SAND domain
  7. XM_011540518.3XP_011538820.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011538820.1

    UniProtKB/Swiss-Prot
    B1AT48, Q9NWH1, Q9UKD0, Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
    Conserved Domains (1) summary
    pfam01342
    Location:90165
    SAND; SAND domain
  8. XM_047438233.1XP_047294189.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B1AT47, B2RCN8
  9. XM_047438316.1XP_047294272.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B1AT47, B2RCN8
  10. XM_011540522.4XP_011538824.1  glucocorticoid modulatory element-binding protein 1 isoform X3

    Conserved Domains (1) summary
    pfam15449
    Location:168256
    Retinal; Retinal protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    28510195..28561345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333897.1XP_054189872.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B1AT48, Q9NWH1, Q9UKD0, Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
  2. XM_054333904.1XP_054189879.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B1AT47, B2RCN8
  3. XM_054333901.1XP_054189876.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B1AT48, Q9NWH1, Q9UKD0, Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
  4. XM_054333900.1XP_054189875.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B1AT48, Q9NWH1, Q9UKD0, Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
  5. XM_054333899.1XP_054189874.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B1AT48, Q9NWH1, Q9UKD0, Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
  6. XM_054333903.1XP_054189878.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B1AT47, B2RCN8
  7. XM_054333898.1XP_054189873.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B1AT48, Q9NWH1, Q9UKD0, Q9Y692
    UniProtKB/TrEMBL
    B2RCN8
  8. XM_054333902.1XP_054189877.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B1AT47, B2RCN8
  9. XM_054333905.1XP_054189880.1  glucocorticoid modulatory element-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    B1AT47, B2RCN8
  10. XM_054333906.1XP_054189881.1  glucocorticoid modulatory element-binding protein 1 isoform X3