U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PNMA2 PNMA family member 2 [ Homo sapiens (human) ]

Gene ID: 10687, updated on 13-May-2022

Summary

Official Symbol
PNMA2provided by HGNC
Official Full Name
PNMA family member 2provided by HGNC
Primary source
HGNC:HGNC:9159
See related
Ensembl:ENSG00000240694 MIM:603970; AllianceGenome:HGNC:9159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MA2; MM2; RGAG2
Summary
Predicted to be involved in positive regulation of apoptotic process. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 63.2), adrenal (RPKM 6.1) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PNMA2 in Genome Data Viewer
Location:
8p21.2
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (26504701..26513872, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (26781276..26790451, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26362217..26371388, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene DNAJB6 pseudogene 2 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene Sharpr-MPRA regulatory region 13991 Neighboring gene dihydropyrimidinase like 2 Neighboring gene proteasome activator subunit 2 pseudogene 5 Neighboring gene uncharacterized LOC124901916

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0883

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
paraneoplastic antigen Ma2
Names
40 kDa neuronal protein
onconeuronal antigen MA2
paraneoplastic Ma antigen 2
paraneoplastic neuronal antigen MM2
retrotransposon gag domain containing 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007257.6NP_009188.1  paraneoplastic antigen Ma2

    See identical proteins and their annotated locations for NP_009188.1

    Status: VALIDATED

    Source sequence(s)
    AB020690, BC036489, BC047515, DA779744
    Consensus CDS
    CCDS34868.1
    UniProtKB/Swiss-Prot
    Q9UL42
    UniProtKB/TrEMBL
    Q5U5Z3
    Related
    ENSP00000429344.1, ENST00000522362.7
    Conserved Domains (1) summary
    pfam14893
    Location:1327
    PNMA; PNMA

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    26504701..26513872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544365.4XP_011542667.1  paraneoplastic antigen Ma2 isoform X1

    See identical proteins and their annotated locations for XP_011542667.1

    UniProtKB/Swiss-Prot
    Q9UL42
    Conserved Domains (1) summary
    pfam14893
    Location:1327
    PNMA; PNMA

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    26781276..26790451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)