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Rab31 RAB31, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 106572, updated on 26-Sep-2022

Summary

Official Symbol
Rab31provided by MGI
Official Full Name
RAB31, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1914603
See related
Ensembl:ENSMUSG00000056515 AllianceGenome:MGI:1914603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab22B; 1700093E07Rik
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in positive regulation of phagocytosis, engulfment. Located in early phagosome membrane and phagocytic cup. Is expressed in axial musculature; ganglia; medulla oblongata basal plate; submandibular gland primordium; and vibrissa. Orthologous to human RAB31 (RAB31, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 24.0), cortex adult (RPKM 19.7) and 27 other tissues See more
Orthologs
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Genomic context

See Rab31 in Genome Data Viewer
Location:
17; 17 E1.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (65958721..66079747, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65651726..65772752, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene vesicle-associated membrane protein, associated protein A Neighboring gene thioredoxin domain containing 2 (spermatozoa) Neighboring gene predicted gene, 35477 Neighboring gene protein phosphatase 4, regulatory subunit 1 Neighboring gene ralA binding protein 1 Neighboring gene predicted gene, 49870

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in Golgi vesicle transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagosome maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis, engulfment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulated exocytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early phagosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133685.2NP_598446.2  ras-related protein Rab-31

    See identical proteins and their annotated locations for NP_598446.2

    Status: VALIDATED

    Source sequence(s)
    AC139751, AC166058, AK051270, AK159095, BY761495
    Consensus CDS
    CCDS50166.1
    UniProtKB/Swiss-Prot
    Q921E2
    UniProtKB/TrEMBL
    A0A8C6IH41, Q3TXV4
    Related
    ENSMUSP00000068195.8, ENSMUST00000070673.9
    Conserved Domains (2) summary
    cd01860
    Location:6168
    Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
    pfam00071
    Location:8168
    Ras; Ras family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    65958721..66079747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160241.1XP_036016134.1  ras-related protein Rab-31 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:1125
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases