YKT6 YKT6 v-SNARE homolog [Homo sapiens (human)] - Gene

Summary

Official Symbol: YKT6provided by HGNC
Official Full Name: YKT6 v-SNARE homologprovided by HGNC
Primary source: HGNC:HGNC:16959
See related: Ensembl:ENSG00000106636 MIM:606209; AllianceGenome:HGNC:16959
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 24.8), colon (RPKM 21.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (44200978..44214294)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (44359565..44372881)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (44240577..44253893)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A pan-cancer analysis of the oncogenic role of YKT6 in human tumors.
Title: A pan-cancer analysis of the oncogenic role of YKT6 in human tumors.
High expression of YKT6 associated with progression and poor prognosis of hepatocellular carcinoma.
Title: High expression of YKT6 associated with progression and poor prognosis of hepatocellular carcinoma.
YKT6, as a potential predictor of prognosis and immunotherapy response for oral squamous cell carcinoma, is related to cell invasion, metastasis, and CD8+ T cell infiltration.
Title: YKT6, as a potential predictor of prognosis and immunotherapy response for oral squamous cell carcinoma, is related to cell invasion, metastasis, and CD8+ T cell infiltration.
Proinflammatory macrophage-derived microvesicles exhibit tumor tropism dependent on CCL2/CCR2 signaling axis and promote drug delivery via SNARE-mediated membrane fusion.
Title: Proinflammatory macrophage-derived microvesicles exhibit tumor tropism dependent on CCL2/CCR2 signaling axis and promote drug delivery via SNARE-mediated membrane fusion.
A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus.
Title: A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus.
Parkinson's disease alpha-synuclein perturbs the physiological response to lysosomal stress by impeding the SNARE protein ykt6
Title: Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein.
The observed anti-migratory activity of Ykt6 is mediated by a unique mechanism involving the expressional upregulation of microRNA 145, which selectively decreases the cellular level of Junctional Adhesion Molecule (JAM) A.
Title: A membrane fusion protein, Ykt6, regulates epithelial cell migration via microRNA-mediated suppression of Junctional Adhesion Molecule A.
YKT6 forms a SNARE complex with SNAP29 and lysosomal STX7, both of which are required for autophagosomal fusion.
Title: Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17.
YKT6 is a key molecule in the regulation of exosome release in lung cancer cells and is in turn precisely regulated by miR-134 and miR-135b. Moreover, YKT6 levels impact prognosis of resected Non small cell lung cancer patients.
Title: YKT6 expression, exosome release, and survival in non-small cell lung cancer.
mRNA expression of CCT5, RGS3, and YKT6 was significantly up-regulated in p53-mutated tumors and associated with a low response rate to docetaxel.
Title: Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S2060E (e-PCR)
- UniSTS:58627

RH12548 (e-PCR)
- UniSTS:14367

STS-AA037832 (e-PCR)
- UniSTS:34641

GDB:594252 (e-PCR)
- UniSTS:5745

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables SNAP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables protein-cysteine S-palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane fusion	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle docking involved in exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle targeting	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
part_of SNARE complex	ISS Inferred from Sequence or Structural Similarity more info
part_of SNARE complex	TAS Traceable Author Statement more info	PubMed
located_in apical dendrite	IEA Inferred from Electronic Annotation more info
located_in basal dendrite	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	TAS Traceable Author Statement more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle	TAS Traceable Author Statement more info

General protein information

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Preferred Names: synaptobrevin homolog YKT6

Names: R-SNARE; SNARE protein Ykt6; YKT6 v-SNARE protein; YKT6, S. cerevisiae, homolog of

NP_001350607.1

EC 2.3.1.-

NP_001397803.1

EC 2.3.1.-

NP_006546.1

EC 2.3.1.-

XP_054184398.1

EC 2.3.1.-

XP_054213078.1

EC 2.3.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363678.2 → NP_001350607.1 synaptobrevin homolog YKT6 isoform 2

Status: REVIEWED

Source sequence(s)

AC006454, AK299158, BC007319

Consensus CDS

CCDS87497.1

Related

ENSP00000420805.1, ENST00000496112.5

Conserved Domains (2) summary

pfam13774
Location:44 → 116

Longin; Regulated-SNARE-like domain

cl26083
Location:3 → 155

Synaptobrevin; Synaptobrevin
NM_001410874.1 → NP_001397803.1 synaptobrevin homolog YKT6 isoform 3

Status: REVIEWED

Source sequence(s)

AC006454

Consensus CDS

CCDS94093.1

UniProtKB/TrEMBL

A0A7I2V4L6
NM_006555.4 → NP_006546.1 synaptobrevin homolog YKT6 isoform 1

See identical proteins and their annotated locations for NP_006546.1

Status: REVIEWED

Source sequence(s)

AC006454, AU130339, BC007319

Consensus CDS

CCDS5482.1

UniProtKB/Swiss-Prot

O15498, Q6IB15

UniProtKB/TrEMBL

A4D2J0

Related

ENSP00000223369.2, ENST00000223369.3

Conserved Domains (2) summary

COG5143
Location:3 → 198

SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]

cd15867
Location:136 → 195

R-SNARE_YKT6; SNARE motif of YKT6