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YKT6 YKT6 v-SNARE homolog [ Homo sapiens (human) ]

Gene ID: 10652, updated on 14-Sep-2019

Summary

Official Symbol
YKT6provided by HGNC
Official Full Name
YKT6 v-SNARE homologprovided by HGNC
Primary source
HGNC:HGNC:16959
See related
Ensembl:ENSG00000106636 MIM:606209
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 24.8), colon (RPKM 21.7) and 25 other tissues See more
Orthologs

Genomic context

See YKT6 in Genome Data Viewer
Location:
7p13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (44200978..44214294)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44240577..44253893)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375258 Neighboring gene uncharacterized LOC105375257 Neighboring gene glucokinase Neighboring gene calcium/calmodulin dependent protein kinase II beta Neighboring gene NudC domain containing 3 Neighboring gene ribosomal protein L32 pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
protein-cysteine S-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IDA
Inferred from Direct Assay
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
membrane fusion IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
PubMed 
vesicle docking involved in exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
vesicle targeting IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
SNARE complex ISS
Inferred from Sequence or Structural Similarity
more info
 
SNARE complex TAS
Traceable Author Statement
more info
PubMed 
apical dendrite IEA
Inferred from Electronic Annotation
more info
 
basal dendrite IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane TAS
Traceable Author Statement
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
synaptobrevin homolog YKT6
Names
R-SNARE
SNARE protein Ykt6
YKT6 v-SNARE protein
YKT6, S. cerevisiae, homolog of
NP_001350607.1
NP_006546.1
XP_005249639.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363678.2NP_001350607.1  synaptobrevin homolog YKT6 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC006454, AK299158, BC007319
    Consensus CDS
    CCDS87497.1
    Related
    ENSP00000420805.1, ENST00000496112.5
    Conserved Domains (2) summary
    pfam13774
    Location:44116
    Longin; Regulated-SNARE-like domain
    cl26083
    Location:3155
    Synaptobrevin; Synaptobrevin
  2. NM_006555.4NP_006546.1  synaptobrevin homolog YKT6 isoform 1

    See identical proteins and their annotated locations for NP_006546.1

    Status: REVIEWED

    Source sequence(s)
    AC006454, AU130339, BC007319
    Consensus CDS
    CCDS5482.1
    UniProtKB/Swiss-Prot
    O15498
    UniProtKB/TrEMBL
    A4D2J0
    Related
    ENSP00000223369.2, ENST00000223369.3
    Conserved Domains (2) summary
    COG5143
    Location:3198
    SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
    cd15867
    Location:136195
    R-SNARE_YKT6; SNARE motif of YKT6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    44200978..44214294
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249582.4XP_005249639.1  synaptobrevin homolog YKT6 isoform X1

    See identical proteins and their annotated locations for XP_005249639.1

    Conserved Domains (3) summary
    COG5143
    Location:3186
    SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
    cd15867
    Location:136187
    R-SNARE_YKT6; SNARE motif of YKT6
    pfam13774
    Location:44107
    Longin; Regulated-SNARE-like domain
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