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TAF6L TATA-box binding protein associated factor 6 like [ Homo sapiens (human) ]

Gene ID: 10629, updated on 24-Nov-2020

Summary

Official Symbol
TAF6Lprovided by HGNC
Official Full Name
TATA-box binding protein associated factor 6 likeprovided by HGNC
Primary source
HGNC:HGNC:17305
See related
Ensembl:ENSG00000162227 MIM:602946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAF65A
Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 7.9), fat (RPKM 5.1) and 25 other tissues See more
Orthologs

Genomic context

See TAF6L in Genome Data Viewer
Location:
11q12.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62771396..62787342)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62538775..62554814)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 3 Neighboring gene RNA polymerase II subunit G Neighboring gene transmembrane protein 179B Neighboring gene microRNA 6748 Neighboring gene transmembrane protein 223

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4288, FLJ11136

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
chromatin remodeling TAS
Traceable Author Statement
more info
PubMed 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of somatic stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription initiation from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
SAGA complex IEA
Inferred from Electronic Annotation
more info
 
SLIK (SAGA-like) complex IEA
Inferred from Electronic Annotation
more info
 
STAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
STAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
histone deacetylase complex TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Names
PAF65-alpha
PCAF-associated factor 65-alpha
TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
p300/CBP-associated factor (PCAF)-associated factor 65

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006473.4NP_006464.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

    See identical proteins and their annotated locations for NP_006464.1

    Status: REVIEWED

    Source sequence(s)
    AK289499, BC008785, DC311213
    Consensus CDS
    CCDS8035.1
    UniProtKB/Swiss-Prot
    Q9Y6J9
    UniProtKB/TrEMBL
    A0A024R5A7, A8K0D4
    Related
    ENSP00000294168.3, ENST00000294168.8
    Conserved Domains (2) summary
    pfam02969
    Location:973
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:153365
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62771396..62787342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273714.2XP_005273771.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X1

    Conserved Domains (2) summary
    pfam02969
    Location:973
    TAF; TATA box binding protein associated factor (TAF)
    cd08050
    Location:145356
    TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)
  2. XM_017017100.2XP_016872589.1  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L isoform X2

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