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ARID3B AT-rich interaction domain 3B [ Homo sapiens (human) ]

Gene ID: 10620, updated on 17-Nov-2020

Summary

Official Symbol
ARID3Bprovided by HGNC
Official Full Name
AT-rich interaction domain 3Bprovided by HGNC
Primary source
HGNC:HGNC:14350
See related
Ensembl:ENSG00000179361 MIM:612457
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BDP; DRIL2
Summary
This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 16.7), placenta (RPKM 10.6) and 19 other tissues See more
Orthologs

Genomic context

See ARID3B in Genome Data Viewer
Location:
15q24.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74541220..74598131)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74833518..74890472)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene UBL7 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC102723714 Neighboring gene VISTA enhancer hs1510 Neighboring gene Sharpr-MPRA regulatory region 315 Neighboring gene uncharacterized LOC102723750 Neighboring gene CDC like kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies eight loci associated with blood pressure.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
AT-rich interactive domain-containing protein 3B
Names
ARID domain-containing protein 3B
AT rich interactive domain 3B (BRIGHT- like)
bright and dead ringer protein
bright-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307939.2NP_001294868.1  AT-rich interactive domain-containing protein 3B isoform 1

    See identical proteins and their annotated locations for NP_001294868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC100835, AF116846, BC041792, DC396899
    Consensus CDS
    CCDS76777.1
    UniProtKB/Swiss-Prot
    Q8IVW6
    Related
    ENSP00000477878.1, ENST00000622429.1
    Conserved Domains (1) summary
    smart00501
    Location:216305
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
  2. NM_006465.4NP_006456.1  AT-rich interactive domain-containing protein 3B isoform 2

    See identical proteins and their annotated locations for NP_006456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC100835, AF116846, DC396899
    Consensus CDS
    CCDS10264.1
    UniProtKB/Swiss-Prot
    Q8IVW6
    Related
    ENSP00000343126.5, ENST00000346246.9
    Conserved Domains (1) summary
    smart00501
    Location:216305
    BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74541220..74598131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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