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STAMBP STAM binding protein [ Homo sapiens (human) ]

Gene ID: 10617, updated on 11-Sep-2019

Summary

Official Symbol
STAMBPprovided by HGNC
Official Full Name
STAM binding proteinprovided by HGNC
Primary source
HGNC:HGNC:16950
See related
Ensembl:ENSG00000124356 MIM:606247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMSH; MICCAP
Summary
Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 4.9), brain (RPKM 4.5) and 25 other tissues See more
Orthologs

Genomic context

See STAMBP in Genome Data Viewer
Location:
2p13.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (73828911..73873656)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74056043..74100783)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 11 Neighboring gene chromosome 2 open reading frame 78 Neighboring gene uncharacterized LOC105374807 Neighboring gene uncharacterized LOC112268419 Neighboring gene zinc finger DHHC-type containing 6 pseudogene Neighboring gene actin gamma 2, smooth muscle

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
    Internalization of ErbB1, organism-specific biosystem
    Internalization of ErbB1
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Metalloprotease DUBs, organism-specific biosystem (from REACTOME)
    Metalloprotease DUBs, organism-specific biosystemThe JAB1/MPN +/MOV34 (JAMM) domain metalloproteases cleave the isopeptide bond at or near the the attachment point of polyubiquitin and substrate. PSMD14 (RPN11), STAMBP (AMSH), STAMBPL1 (AMSH-LP), a...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126516, MGC126518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Lys63-specific deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
protein K63-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
STAM-binding protein
Names
associated molecule with the SH3 domain of STAM
endosome-associated ubiquitin isopeptidase
testicular secretory protein Li 54
NP_001340896.1
NP_001340897.1
NP_001340898.1
NP_001340899.1
NP_001340900.1
NP_001340901.1
NP_001340902.1
NP_001340903.1
NP_001340904.1
NP_001340905.1
NP_006454.1
NP_964010.1
NP_998787.1
XP_011530785.1
XP_011530787.1
XP_024308301.1
XP_024308302.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033223.2 RefSeqGene

    Range
    5001..43258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001353967.1NP_001340896.1  STAM-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Consensus CDS
    CCDS1929.1
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  2. NM_001353968.1NP_001340897.1  STAM-binding protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Consensus CDS
    CCDS1929.1
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  3. NM_001353969.1NP_001340898.1  STAM-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Conserved Domains (2) summary
    cd08066
    Location:254405
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  4. NM_001353970.1NP_001340899.1  STAM-binding protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Conserved Domains (2) summary
    cd08066
    Location:254405
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  5. NM_001353971.1NP_001340900.1  STAM-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Conserved Domains (1) summary
    cd08066
    Location:119289
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  6. NM_001353972.1NP_001340901.1  STAM-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Conserved Domains (1) summary
    cd08066
    Location:119289
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  7. NM_001353973.1NP_001340902.1  STAM-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Conserved Domains (1) summary
    cd08066
    Location:119289
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  8. NM_001353974.1NP_001340903.1  STAM-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Conserved Domains (1) summary
    cd08066
    Location:119289
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  9. NM_001353975.1NP_001340904.1  STAM-binding protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Conserved Domains (1) summary
    cd08066
    Location:119289
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  10. NM_001353976.1NP_001340905.1  STAM-binding protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC073046
    Conserved Domains (1) summary
    cd08066
    Location:119270
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  11. NM_006463.5NP_006454.1  STAM-binding protein isoform 1

    See identical proteins and their annotated locations for NP_006454.1

    Status: REVIEWED

    Source sequence(s)
    AC073046, BC101467, DB477012, DR158757
    Consensus CDS
    CCDS1929.1
    UniProtKB/Swiss-Prot
    O95630
    UniProtKB/TrEMBL
    A0A140VK54
    Related
    ENSP00000377636.1, ENST00000394073.5
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  12. NM_201647.3NP_964010.1  STAM-binding protein isoform 1

    See identical proteins and their annotated locations for NP_964010.1

    Status: REVIEWED

    Source sequence(s)
    AC073046, DN919763, U73522
    Consensus CDS
    CCDS1929.1
    UniProtKB/Swiss-Prot
    O95630
    UniProtKB/TrEMBL
    A0A140VK54
    Related
    ENSP00000344742.3, ENST00000339566.7
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  13. NM_213622.4NP_998787.1  STAM-binding protein isoform 1

    See identical proteins and their annotated locations for NP_998787.1

    Status: REVIEWED

    Source sequence(s)
    AC073046, BC065574, CX758449
    Consensus CDS
    CCDS1929.1
    UniProtKB/Swiss-Prot
    O95630
    UniProtKB/TrEMBL
    A0A140VK54
    Related
    ENSP00000377633.2, ENST00000394070.7
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain

RNA

  1. NR_148668.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073046
  2. NR_148669.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073046
  3. NR_148670.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073046
  4. NR_148671.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC073046

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    73828911..73873656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452533.1XP_024308301.1  STAM-binding protein isoform X2

    Conserved Domains (2) summary
    cd08066
    Location:254405
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  2. XM_024452534.1XP_024308302.1  STAM-binding protein isoform X4

    Conserved Domains (1) summary
    cd08066
    Location:119270
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
  3. XM_011532483.3XP_011530785.1  STAM-binding protein isoform X1

    See identical proteins and their annotated locations for XP_011530785.1

    UniProtKB/Swiss-Prot
    O95630
    UniProtKB/TrEMBL
    A0A140VK54
    Related
    ENSP00000386548.1, ENST00000409707.5
    Conserved Domains (2) summary
    cd08066
    Location:254424
    MPN_AMSH_like; Mov34/MPN/PAD-1 family
    pfam08969
    Location:7114
    USP8_dimer; USP8 dimerisation domain
  4. XM_011532485.3XP_011530787.1  STAM-binding protein isoform X3

    Related
    ENSP00000413874.2, ENST00000432295.6
    Conserved Domains (2) summary
    pfam08969
    Location:13114
    USP8_dimer; USP8 dimerization domain
    cl13996
    Location:254335
    MPN; Mpr1p, Pad1p N-terminal (MPN) domains
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