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DRAP1 DR1 associated protein 1 [ Homo sapiens (human) ]

Gene ID: 10589, updated on 9-Dec-2018

Summary

Official Symbol
DRAP1provided by HGNC
Official Full Name
DR1 associated protein 1provided by HGNC
Primary source
HGNC:HGNC:3019
See related
Ensembl:ENSG00000175550 MIM:602289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NC2-alpha
Summary
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 51.3), fat (RPKM 37.1) and 25 other tissues See more
Orthologs

Genomic context

See DRAP1 in Genome Data Viewer
Location:
11q13.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (65919257..65921577)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65686728..65689048)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NFE2L2 motif-containing MPRA enhancer 146/147 Neighboring gene chromosome 11 open reading frame 68 Neighboring gene uncharacterized LOC105369349 Neighboring gene uncharacterized LOC105369350 Neighboring gene testis specific 10 interacting protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Activin, organism-specific biosystem (from REACTOME)
    Signaling by Activin, organism-specific biosystemActivin was initially discovered as an activator of follicle stimulating hormone in the pituitary gland. It has since been shown to be an important participant in the differentiation of embryonic cel...
  • Signaling by NODAL, organism-specific biosystem (from REACTOME)
    Signaling by NODAL, organism-specific biosystemSignaling by NODAL is essential for patterning of the axes of the embryo and formation of mesoderm and endoderm (reviewed in Schier 2009, Shen 2007). The NODAL proprotein is secreted and cleaved extr...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dr1-associated corepressor
Names
negative co-factor 2-alpha
negative cofactor 2 alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006442.4NP_006433.2  dr1-associated corepressor

    See identical proteins and their annotated locations for NP_006433.2

    Status: REVIEWED

    Source sequence(s)
    BC010025, BG036132, BQ773919
    Consensus CDS
    CCDS8123.1
    UniProtKB/Swiss-Prot
    Q14919
    Related
    ENSP00000307850.2, ENST00000312515.6
    Conserved Domains (1) summary
    cl28542
    Location:292
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    65919257..65921577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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