U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DRAP1 DR1 associated protein 1 [ Homo sapiens (human) ]

Gene ID: 10589, updated on 23-Nov-2023

Summary

Official Symbol
DRAP1provided by HGNC
Official Full Name
DR1 associated protein 1provided by HGNC
Primary source
HGNC:HGNC:3019
See related
Ensembl:ENSG00000175550 MIM:602289; AllianceGenome:HGNC:3019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NC2-alpha
Summary
Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 51.3), fat (RPKM 37.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DRAP1 in Genome Data Viewer
Location:
11q13.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (65919426..65921563)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (65912504..65914641)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65686897..65689034)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65661089-65661593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5021 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:65666730-65666957 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3567 Neighboring gene FOS like 1, AP-1 transcription factor subunit Neighboring gene CRISPRi-validated cis-regulatory element chr11.3338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5022 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:65682731-65683930 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:65685650-65686569 and GRCh37_chr11:65686570-65687490 Neighboring gene chromosome 11 open reading frame 68 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3343 Neighboring gene NANOG hESC enhancer GRCh37_chr11:65704708-65705232 Neighboring gene uncharacterized LOC105369350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65708489-65708988 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:65708959-65709182 Neighboring gene testis specific 10 interacting protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:65729063-65729850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:65733572-65734072 Neighboring gene spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of negative cofactor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
dr1-associated corepressor
Names
negative co-factor 2-alpha
negative cofactor 2 alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006442.4NP_006433.2  dr1-associated corepressor

    See identical proteins and their annotated locations for NP_006433.2

    Status: REVIEWED

    Source sequence(s)
    BC010025, BG036132, BQ773919
    Consensus CDS
    CCDS8123.1
    UniProtKB/Swiss-Prot
    Q13448, Q14919
    UniProtKB/TrEMBL
    E9PQX9
    Related
    ENSP00000307850.2, ENST00000312515.7
    Conserved Domains (1) summary
    COG5247
    Location:292
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    65919426..65921563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    65912504..65914641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)