MRPL28 mitochondrial ribosomal protein L28 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MRPL28provided by HGNC
Official Full Name: mitochondrial ribosomal protein L28provided by HGNC
Primary source: HGNC:HGNC:14484
See related: Ensembl:ENSG00000086504 MIM:604853; Vega:OTTHUMG00000047994
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p15; MAAT1
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 24.9), kidney (RPKM 19.3) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 16p13.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	16	NC_000016.10 (367384..370569, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (417384..420584, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from BioSystems

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Mitochondrial translation, organism-specific biosystem (from REACTOME)
Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
Ribosome, organism-specific biosystem (from KEGG)
Ribosome, organism-specific biosystem
Ribosome
Ribosome, conserved biosystem (from KEGG)
Ribosome, conserved biosystem
Ribosome

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-AA029713 (e-PCR)
- UniSTS:54587

ECD05459 (e-PCR)
- UniSTS:286525

RH45380 (e-PCR)
- UniSTS:56893

ECD07269 (e-PCR)
- UniSTS:288324

RH15994 (e-PCR)
- UniSTS:38987

NIB1488 (e-PCR)
- UniSTS:24417

ECD07089 (e-PCR)
- UniSTS:288147

REN95715 (e-PCR)
- UniSTS:420513

REN95716 (e-PCR)
- UniSTS:420514

REN95717 (e-PCR)
- UniSTS:420515

REN95718 (e-PCR)
- UniSTS:420516

REN95719 (e-PCR)
- UniSTS:420517

REN95720 (e-PCR)
- UniSTS:420518

REN95721 (e-PCR)
- UniSTS:420519

REN95722 (e-PCR)
- UniSTS:420520

REN95723 (e-PCR)
- UniSTS:420521

REN95724 (e-PCR)
- UniSTS:420522

REN95725 (e-PCR)
- UniSTS:420523

REN95726 (e-PCR)
- UniSTS:420524

REN95727 (e-PCR)
- UniSTS:420525

REN95728 (e-PCR)
- UniSTS:420526

REN95729 (e-PCR)
- UniSTS:420527

REN95732 (e-PCR)
- UniSTS:420530

REN95733 (e-PCR)
- UniSTS:420531

REN95734 (e-PCR)
- UniSTS:420532

REN95735 (e-PCR)
- UniSTS:420533

REN95736 (e-PCR)
- UniSTS:420534

REN95737 (e-PCR)
- UniSTS:420535

REN95738 (e-PCR)
- UniSTS:420536

REN95739 (e-PCR)
- UniSTS:420537

ECD06117 (e-PCR)
- UniSTS:287179

ECD06118 (e-PCR)
- UniSTS:287180

ECD06940 (e-PCR)
- UniSTS:287998

Homology

Homologs of the MRPL28 gene: The MRPL28 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, C.elegans, and frog.
Orthologs from Annotation Pipeline: 228 organisms have orthologs with human gene MRPL28
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
RNA binding	HDA more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
structural constituent of ribosome	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
mitochondrial translational elongation	TAS Traceable Author Statement more info
mitochondrial translational termination	TAS Traceable Author Statement more info
translation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytosol	IDA Inferred from Direct Assay more info
mitochondrial inner membrane	TAS Traceable Author Statement more info
mitochondrial large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info	PubMed
mitochondrial large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
mitochondrial ribosome	IDA Inferred from Direct Assay more info	PubMed
mitochondrial ribosome	NAS Non-traceable Author Statement more info	PubMed
mitochondrion	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: 39S ribosomal protein L28, mitochondrial

Names: L28mt; MRP-L28; melanoma antigen p15; melanoma-associated antigen recognised by cytotoxic T lymphocytes; melanoma-associated antigen recognized by T-lymphocytes; mitochondrial large ribosomal subunit protein bL28m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.