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MRPL28 mitochondrial ribosomal protein L28 [ Homo sapiens (human) ]

Gene ID: 10573, updated on 7-Jan-2024

Summary

Official Symbol
MRPL28provided by HGNC
Official Full Name
mitochondrial ribosomal protein L28provided by HGNC
Primary source
HGNC:HGNC:14484
See related
Ensembl:ENSG00000086504 MIM:604853; AllianceGenome:HGNC:14484
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p15; MAAT1; bL28m
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein, a part of which was originally isolated by its ability to recognize tyrosinase in an HLA-A24-restricted fashion. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 24.9), kidney (RPKM 19.3) and 25 other tissues See more
Orthologs
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Genomic context

See MRPL28 in Genome Data Viewer
Location:
16p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (366969..370538, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (361841..366186, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (416969..420538, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase family A member 2 Neighboring gene axin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:359414-359928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:359929-360443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:366745-367498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:367499-368250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:368251-369004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:374949-375556 Neighboring gene Sharpr-MPRA regulatory region 4309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:389458-390182 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:391465-392016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6908 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6909 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6911 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:410874-411722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:411723-412570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:413199-413706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:413707-414213 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:414214-414720 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:422268-422839 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:431071-431970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6916 Neighboring gene uncharacterized LOC100134368 Neighboring gene post-GPI attachment to proteins 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:440484-440661 Neighboring gene ribosomal protein L23a pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:449109-449694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:450865-451450 Neighboring gene NME/NM23 nucleoside diphosphate kinase 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC8499

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial ribosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial ribosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
large ribosomal subunit protein bL28m
Names
39S ribosomal protein L28, mitochondrial
L28mt
MRP-L28
melanoma antigen p15
melanoma-associated antigen recognised by cytotoxic T lymphocytes
melanoma-associated antigen recognized by T-lymphocytes
mitochondrial large ribosomal subunit protein bL28m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052909.1 RefSeqGene

    Range
    5032..8601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006428.5NP_006419.2  large ribosomal subunit protein bL28m

    See identical proteins and their annotated locations for NP_006419.2

    Status: REVIEWED

    Source sequence(s)
    AC005202, BC000507, BI862386, BM967049, DB469296, Z97634
    Consensus CDS
    CCDS32349.1
    UniProtKB/Swiss-Prot
    B2RCM4, D3DU46, Q13084, Q4TT39, Q96S26, Q9BQD8, Q9BR04
    UniProtKB/TrEMBL
    A2IDC6
    Related
    ENSP00000199706.7, ENST00000199706.13
    Conserved Domains (1) summary
    pfam00830
    Location:88136
    Ribosomal_L28; Ribosomal L28 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    366969..370538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522351.3XP_011520653.1  large ribosomal subunit protein bL28m isoform X1

    See identical proteins and their annotated locations for XP_011520653.1

    UniProtKB/Swiss-Prot
    B2RCM4, D3DU46, Q13084, Q4TT39, Q96S26, Q9BQD8, Q9BR04
    UniProtKB/TrEMBL
    A2IDC6
    Related
    ENSP00000374326.2, ENST00000389675.6
    Conserved Domains (1) summary
    pfam00830
    Location:88136
    Ribosomal_L28; Ribosomal L28 family
  2. XM_005255041.3XP_005255098.1  large ribosomal subunit protein bL28m isoform X1

    See identical proteins and their annotated locations for XP_005255098.1

    UniProtKB/Swiss-Prot
    B2RCM4, D3DU46, Q13084, Q4TT39, Q96S26, Q9BQD8, Q9BR04
    UniProtKB/TrEMBL
    A2IDC6
    Related
    ENSP00000390399.1, ENST00000447696.5
    Conserved Domains (1) summary
    pfam00830
    Location:88136
    Ribosomal_L28; Ribosomal L28 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    361841..366186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379392.1XP_054235367.1  large ribosomal subunit protein bL28m isoform X1

    UniProtKB/Swiss-Prot
    B2RCM4, D3DU46, Q13084, Q4TT39, Q96S26, Q9BQD8, Q9BR04
    UniProtKB/TrEMBL
    A2IDC6