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DPYSL4 dihydropyrimidinase like 4 [ Homo sapiens (human) ]

Gene ID: 10570, updated on 4-Jun-2020

Summary

Official Symbol
DPYSL4provided by HGNC
Official Full Name
dihydropyrimidinase like 4provided by HGNC
Primary source
HGNC:HGNC:3016
See related
Ensembl:ENSG00000151640 MIM:608407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRMP3; DRP-4; ULIP4
Expression
Biased expression in brain (RPKM 6.6), heart (RPKM 2.6) and 6 other tissues See more
Orthologs

Genomic context

See DPYSL4 in Genome Data Viewer
Location:
10q26.3
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (132184983..132205759)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (133998564..134019280)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit Bdelta Neighboring gene BCL2 interacting protein 3 Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene uncharacterized LOC105378567 Neighboring gene serine/threonine kinase 32C Neighboring gene Sharpr-MPRA regulatory region 5064 Neighboring gene leucine rich repeat containing 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT dihydropyrimidinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
filamin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neuron death IEA
Inferred from Electronic Annotation
more info
 
neuron projection guidance IEA
Inferred from Electronic Annotation
more info
 
NOT pyrimidine nucleobase catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dihydropyrimidinase-related protein 4
Names
CRMP-3
ULIP-4
UNC33-like phosphoprotein 4
collapsin response mediator protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006426.3NP_006417.2  dihydropyrimidinase-related protein 4

    See identical proteins and their annotated locations for NP_006417.2

    Status: VALIDATED

    Source sequence(s)
    AL512622, BC029280, BC136329, BC142974
    Consensus CDS
    CCDS7665.1
    UniProtKB/Swiss-Prot
    O14531
    Related
    ENSP00000339850.3, ENST00000338492.9
    Conserved Domains (1) summary
    cd01314
    Location:17466
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    132184983..132205759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252658.3XP_005252715.1  dihydropyrimidinase-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_005252715.1

    UniProtKB/TrEMBL
    D3DRG7
    Related
    ENSP00000357616.1, ENST00000368627.1
    Conserved Domains (1) summary
    cd01314
    Location:1403
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  2. XM_011539125.2XP_011537427.1  dihydropyrimidinase-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011537427.1

    UniProtKB/TrEMBL
    D3DRG7
    Conserved Domains (1) summary
    cd01314
    Location:1403
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  3. XM_017015483.1XP_016870972.1  dihydropyrimidinase-related protein 4 isoform X1

    UniProtKB/TrEMBL
    D3DRG7
    Conserved Domains (1) summary
    cd01314
    Location:1403
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
  4. XM_017015482.1XP_016870971.1  dihydropyrimidinase-related protein 4 isoform X1

    UniProtKB/TrEMBL
    D3DRG7
    Conserved Domains (1) summary
    cd01314
    Location:1403
    D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
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