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SLC34A2 solute carrier family 34 member 2 [ Homo sapiens (human) ]

Gene ID: 10568, updated on 4-Oct-2020

Summary

Official Symbol
SLC34A2provided by HGNC
Official Full Name
solute carrier family 34 member 2provided by HGNC
Primary source
HGNC:HGNC:11020
See related
Ensembl:ENSG00000157765 MIM:604217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PULAM; NPTIIb; NAPI-3B; NAPI-IIb
Summary
The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Expression
Restricted expression toward lung (RPKM 380.9) See more
Orthologs

Genomic context

See SLC34A2 in Genome Data Viewer
Location:
4p15.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (25655851..25678748)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25656853..25680735)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 126 pseudogene Neighboring gene S-phase kinase associated protein 1 pseudogene Neighboring gene ribosomal protein S29 pseudogene 11 Neighboring gene SLIRP. pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90534

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphate ion binding IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
sodium:phosphate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sodium:phosphate symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular phosphate ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular phosphate ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
phosphate ion transport IDA
Inferred from Direct Assay
more info
PubMed 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sodium-dependent phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
brush border IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
vesicle HDA PubMed 
vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sodium-dependent phosphate transport protein 2B
Names
sodium/phosphate cotransporter 2B
solute carrier family 34 (sodium phosphate), member 2
solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
type II sodium-dependent phosphate transporter 3b

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021185.1 RefSeqGene

    Range
    5001..27936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177998.2NP_001171469.2  sodium-dependent phosphate transport protein 2B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC092436
    Consensus CDS
    CCDS54750.1
    Related
    ENSP00000425501.1, ENST00000504570.5
    Conserved Domains (1) summary
    TIGR01013
    Location:104603
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  2. NM_001177999.2NP_001171470.2  sodium-dependent phosphate transport protein 2B isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC092436
    Consensus CDS
    CCDS54750.1
    Related
    ENSP00000423021.1, ENST00000503434.5
  3. NM_006424.3NP_006415.3  sodium-dependent phosphate transport protein 2B isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC092436
    Consensus CDS
    CCDS3435.1
    Related
    ENSP00000371483.3, ENST00000382051.8
    Conserved Domains (1) summary
    TIGR01013
    Location:105604
    2a58; Phosphate:Na+ Symporter (PNaS) Family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    25655851..25678748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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