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Phyhip phytanoyl-CoA hydroxylase interacting protein [ Mus musculus (house mouse) ]

Gene ID: 105653, updated on 26-Sep-2022

Summary

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Official Symbol
Phyhipprovided by MGI
Official Full Name
phytanoyl-CoA hydroxylase interacting proteinprovided by MGI
Primary source
MGI:MGI:1860417
See related
Ensembl:ENSMUSG00000003469 AllianceGenome:MGI:1860417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lnap1ip; PAHX-AP1; PAHX-AP#1; C630010D02Rik
Summary
Predicted to enable protein tyrosine kinase binding activity. Predicted to be involved in protein localization. Predicted to be active in cytoplasm. Is expressed in several structures, including aorta; central nervous system; musculoskeletal system; nose; and skin. Orthologous to human PHYHIP (phytanoyl-CoA 2-hydroxylase interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 89.9), cortex adult (RPKM 83.2) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Phyhip in Genome Data Viewer
Location:
14; 14 D2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70694957..70706266)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70457517..70468826)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) III (DNA directed) polypeptide D Neighboring gene microRNA 320 Neighboring gene bone morphogenetic protein 1 Neighboring gene predicted gene, 52136 Neighboring gene surfactant associated protein C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Changes underlying arrhythmia in the transgenic heart overexpressing Refsum disease gene-associated protein. Koh JT, et al. Biochem Biophys Res Commun, 2004 Jan 2. PMID 14672712
  2. Cardiac Characteristics of Transgenic Mice Overexpressing Refsum Disease Gene-Associated Protein within the Heart. Koh JT, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527414
  3. Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein. Koh JT, et al. Brain Res Mol Brain Res, 2001 Mar 5. PMID 11245925
  4. Identification of a brain specific protein that associates with a refsum disease gene product, phytanoyl-CoA alpha-hydroxylase. Lee ZH, et al. Brain Res Mol Brain Res, 2000 Feb 22. PMID 10686344
  5. A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Kim MY, et al. Proc Natl Acad Sci U S A, 2006 Aug 29. PMID 16924111, Free PMC Article

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC40960

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phytanoyl-CoA hydroxylase-interacting protein
Names
PAHXAP1
lupus nephritis-associated peptide 1 interacting protein
phytanoyl-CoA hydroxylase-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145981.3 → NP_666093.1  phytanoyl-CoA hydroxylase-interacting protein

    See identical proteins and their annotated locations for NP_666093.1

    Status: PROVISIONAL

    Source sequence(s)
    AK049900
    Consensus CDS
    CCDS36971.1
    UniProtKB/Swiss-Prot
    Q8K0S0
    UniProtKB/TrEMBL
    A0A6P7PYT4, A0A8C6N513, B9EIC7
    Related
    ENSMUSP00000003561.4, ENSMUST00000003561.10
    Conserved Domains (1) summary
    cd00063
    Location:5 → 112
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70694957..70706266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518379.5 → XP_006518442.1  phytanoyl-CoA hydroxylase-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006518442.1

    UniProtKB/Swiss-Prot
    Q8K0S0
    UniProtKB/TrEMBL
    A0A6P7PYT4, A0A8C6N513, B9EIC7
    Conserved Domains (1) summary
    cd00063
    Location:5 → 112
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_006518380.4 → XP_006518443.1  phytanoyl-CoA hydroxylase-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006518443.1

    UniProtKB/Swiss-Prot
    Q8K0S0
    UniProtKB/TrEMBL
    A0A6P7PYT4, A0A8C6N513, B9EIC7
    Conserved Domains (1) summary
    cd00063
    Location:5 → 112
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0S0.1 GenPept UniProtKB/Swiss-Prot:Q8K0S0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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