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RPP38 ribonuclease P/MRP subunit p38 [ Homo sapiens (human) ]

Gene ID: 10557, updated on 23-Nov-2021

Summary

Official Symbol
RPP38provided by HGNC
Official Full Name
ribonuclease P/MRP subunit p38provided by HGNC
Primary source
HGNC:HGNC:30329
See related
Ensembl:ENSG00000152464 MIM:606116
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 13.4), lymph node (RPKM 4.9) and 25 other tissues See more
Orthologs
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Genomic context

See RPP38 in Genome Data Viewer
Location:
10p13
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (15097217..15104257)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15139354..15146256)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ACBD7-DCLRE1CP1 readthrough Neighboring gene acyl-CoA binding domain containing 7 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 45 Neighboring gene RPP38 divergent transcript Neighboring gene uncharacterized LOC105376431 Neighboring gene N-myristoyltransferase 2 Neighboring gene uncharacterized LOC107984210

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonuclease P RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ribonuclease P RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA 5'-leader removal IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in fibrillar center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
 
part_of multimeric ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of multimeric ribonuclease P complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleolar ribonuclease P complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of ribonuclease MRP complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribonuclease P protein subunit p38
Names
RNaseP protein p38
ribonuclease P/MRP 38kDa subunit
NP_001091059.1
NP_001252530.1
NP_006405.2
NP_892117.1
XP_006717426.1
XP_006717427.1
XP_011517595.1
XP_016870968.1
XP_016870969.1
XP_016870970.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097590.3NP_001091059.1  ribonuclease P protein subunit p38

    See identical proteins and their annotated locations for NP_001091059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AW292674, BC029494, CX872398
    Consensus CDS
    CCDS7108.1
    UniProtKB/Swiss-Prot
    P78345
    Related
    ENSP00000367445.1, ENST00000378203.5
    Conserved Domains (1) summary
    pfam01248
    Location:107185
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
  2. NM_001265601.2NP_001252530.1  ribonuclease P protein subunit p38

    See identical proteins and their annotated locations for NP_001252530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AW292674, BC029494, BU180901, BU197354
    Consensus CDS
    CCDS7108.1
    UniProtKB/Swiss-Prot
    P78345
    Related
    ENSP00000478982.1, ENST00000616640.1
    Conserved Domains (1) summary
    pfam01248
    Location:107185
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
  3. NM_006414.5NP_006405.2  ribonuclease P protein subunit p38

    See identical proteins and their annotated locations for NP_006405.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AW292674, BC029494, BP247818
    Consensus CDS
    CCDS7108.1
    UniProtKB/Swiss-Prot
    P78345
    Related
    ENSP00000367444.5, ENST00000378202.5
    Conserved Domains (1) summary
    pfam01248
    Location:107185
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
  4. NM_183005.5NP_892117.1  ribonuclease P protein subunit p38

    See identical proteins and their annotated locations for NP_892117.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AW292674, BC029494, BU197354
    Consensus CDS
    CCDS7108.1
    UniProtKB/Swiss-Prot
    P78345
    Related
    ENSP00000367439.4, ENST00000378197.5
    Conserved Domains (1) summary
    pfam01248
    Location:107185
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    15097217..15104257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015480.2XP_016870969.1  ribonuclease P protein subunit p38 isoform X1

    UniProtKB/Swiss-Prot
    P78345
    Conserved Domains (1) summary
    pfam01248
    Location:107185
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
  2. XM_017015479.2XP_016870968.1  ribonuclease P protein subunit p38 isoform X1

    UniProtKB/Swiss-Prot
    P78345
    Conserved Domains (1) summary
    pfam01248
    Location:107185
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
  3. XM_017015481.2XP_016870970.1  ribonuclease P protein subunit p38 isoform X1

    UniProtKB/Swiss-Prot
    P78345
    Conserved Domains (1) summary
    pfam01248
    Location:107185
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
  4. XM_006717364.4XP_006717427.1  ribonuclease P protein subunit p38 isoform X1

    See identical proteins and their annotated locations for XP_006717427.1

    UniProtKB/Swiss-Prot
    P78345
    Conserved Domains (1) summary
    pfam01248
    Location:107185
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
  5. XM_006717363.2XP_006717426.1  ribonuclease P protein subunit p38 isoform X1

    See identical proteins and their annotated locations for XP_006717426.1

    UniProtKB/Swiss-Prot
    P78345
    Conserved Domains (1) summary
    pfam01248
    Location:107185
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
  6. XM_011519293.2XP_011517595.1  ribonuclease P protein subunit p38 isoform X1

    See identical proteins and their annotated locations for XP_011517595.1

    UniProtKB/Swiss-Prot
    P78345
    Conserved Domains (1) summary
    pfam01248
    Location:107185
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
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