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Chmp7 charged multivesicular body protein 7 [ Mus musculus (house mouse) ]

Gene ID: 105513, updated on 8-Dec-2022

Summary

Official Symbol
Chmp7provided by MGI
Official Full Name
charged multivesicular body protein 7provided by MGI
Primary source
MGI:MGI:1913922
See related
Ensembl:ENSMUSG00000034190 AllianceGenome:MGI:1913922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930596K11Rik; 6330407G04Rik
Summary
Predicted to be involved in several processes, including late endosome to vacuole transport via multivesicular body sorting pathway; midbody abscission; and mitotic nuclear division. Predicted to act upstream of or within protein transport. Predicted to be located in cytosol; nuclear envelope; and nucleoplasm. Predicted to be part of ESCRT III complex. Predicted to be active in multivesicular body. Predicted to colocalize with chromatin. Orthologous to human CHMP7 (charged multivesicular body protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 31.1), whole brain E14.5 (RPKM 26.1) and 28 other tissues See more
Orthologs
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Genomic context

See Chmp7 in Genome Data Viewer
Location:
14; 14 D2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (69954428..69970019, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (69716979..69732570, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene lysyl oxidase-like 2 Neighboring gene microRNA 6950 Neighboring gene R3H domain and coiled-coil containing 1 Neighboring gene RIKEN cDNA 4930480K23 gene Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene PR domain containing 4 pseudogene Neighboring gene tumor necrosis factor receptor superfamily, member 10b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29816

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in autophagosome maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in late endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in late endosome to vacuole transport ISO
Inferred from Sequence Orthology
more info
 
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in membrane fission NAS
Non-traceable Author Statement
more info
PubMed 
involved_in midbody abscission ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
involved_in multivesicular body assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in multivesicular body-lysosome fusion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear membrane reassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleus organization ISO
Inferred from Sequence Orthology
more info
 
involved_in plasma membrane repair ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vacuolar transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle budding from membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle fusion with vacuole NAS
Non-traceable Author Statement
more info
PubMed 
involved_in viral budding from plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in viral budding via host ESCRT complex ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of ESCRT III complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ESCRT III complex ISO
Inferred from Sequence Orthology
more info
 
located_in amphisome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in multivesicular body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
charged multivesicular body protein 7
Names
CHMP family, member 7
chromatin-modifying protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134078.4NP_598839.2  charged multivesicular body protein 7

    See identical proteins and their annotated locations for NP_598839.2

    Status: VALIDATED

    Source sequence(s)
    AK031882, BB621791, BC033365, BY129213, DV645139
    Consensus CDS
    CCDS27242.1
    UniProtKB/Swiss-Prot
    Q8CFW4, Q8R1T1
    UniProtKB/TrEMBL
    Q78V99
    Related
    ENSMUSP00000047700.9, ENSMUST00000036381.10
    Conserved Domains (1) summary
    cl21588
    Location:243390
    Snf7; Snf7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    69954428..69970019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)