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APOBEC3G apolipoprotein B mRNA editing enzyme catalytic subunit 3G [ Macaca nemestrina (pig-tailed macaque) ]

Gene ID: 105464428, updated on 13-Mar-2024

Summary

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Gene symbol
APOBEC3G
Gene description
apolipoprotein B mRNA editing enzyme catalytic subunit 3G
See related
Ensembl:ENSMNEG00000038847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Macaca nemestrina
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human all
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Genomic context

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Location:
chromosome: Un
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Mnem_1.0 (GCF_000956065.1) Unplaced Scaffold NW_012012688.1 (9354741..9365986, complement)

NW_012012688.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3H Neighboring gene DNA dC->dU-editing enzyme APOBEC-3F-like Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3F Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 3D

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012012688 Unplaced Scaffold Reference Mnem_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet. Perkovic M, et al. J Biol Chem, 2009 Feb 27. PMID 19074429, Free PMC Article
  2. Vif substitution enables persistent infection of pig-tailed macaques by human immunodeficiency virus type 1. Thippeshappa R, et al. J Virol, 2011 Apr. PMID 21289128, Free PMC Article
  3. APOBEC3G polymorphism as a selective barrier to cross-species transmission and emergence of pathogenic SIV and AIDS in a primate host. Krupp A, et al. PLoS Pathog, 2013. PMID 24098115, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytidine deaminase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables deoxycytidine deaminase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA cytosine deamination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA demethylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytidine to uridine editing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA dC->dU-editing enzyme APOBEC-3G
Names
apolipoprotein B editing enzyme catalytic polypeptide-like 3G
apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G
apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3G
NP_001292837.1
XP_011710628.1
XP_011710629.1
XP_011710631.1
XP_011710632.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305908.1 → NP_001292837.1  DNA dC->dU-editing enzyme APOBEC-3G

    Status: VALIDATED

    Source sequence(s)
    JZLF01046093, JZLF01046094, JZLF01046095
    UniProtKB/TrEMBL
    U5KJB6
    Related
    ENSMNEP00000030878.1, ENSMNET00000055301.1
    Conserved Domains (3) summary
    cd01283
    Location:24 → 126
    cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
    pfam05240
    Location:312 → 356
    APOBEC_C; APOBEC-like C-terminal domain
    pfam08210
    Location:195 → 368
    APOBEC_N; APOBEC-like N-terminal domain

RefSeqs of Annotated Genomes: Macaca nemestrina Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mnem_1.0

Genomic

  1. NW_012012688.1 Reference Mnem_1.0

    Range
    9354741..9365986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011712327.2 → XP_011710629.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X1

    See identical proteins and their annotated locations for XP_011710629.1

    UniProtKB/TrEMBL
    A0A2K6D4M0, A0A2K6D4P7
    Related
    ENSMNEP00000030872.1, ENSMNET00000055295.1
    Conserved Domains (3) summary
    cd01283
    Location:42 → 144
    cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
    pfam05240
    Location:330 → 374
    APOBEC_C; APOBEC-like C-terminal domain
    pfam08210
    Location:213 → 386
    APOBEC_N; APOBEC-like N-terminal domain

  2. XM_011712326.2 → XP_011710628.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X1

    See identical proteins and their annotated locations for XP_011710628.1

    UniProtKB/TrEMBL
    A0A2K6D4M0, A0A2K6D4P7
    Related
    ENSMNEP00000030908.1, ENSMNET00000055331.1
    Conserved Domains (3) summary
    cd01283
    Location:42 → 144
    cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
    pfam05240
    Location:330 → 374
    APOBEC_C; APOBEC-like C-terminal domain
    pfam08210
    Location:213 → 386
    APOBEC_N; APOBEC-like N-terminal domain

  3. XM_011712330.2 → XP_011710632.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X2

    See identical proteins and their annotated locations for XP_011710632.1

    UniProtKB/TrEMBL
    U5KJB6
    Conserved Domains (3) summary
    cd01283
    Location:144 → 234
    cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
    pfam05240
    Location:252 → 296
    APOBEC_C; APOBEC-like C-terminal domain
    pfam08210
    Location:135 → 308
    APOBEC_N; APOBEC-like N-terminal domain

  4. XM_011712329.1 → XP_011710631.1  DNA dC->dU-editing enzyme APOBEC-3G isoform X2

    See identical proteins and their annotated locations for XP_011710631.1

    UniProtKB/TrEMBL
    U5KJB6
    Conserved Domains (3) summary
    cd01283
    Location:144 → 234
    cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
    pfam05240
    Location:252 → 296
    APOBEC_C; APOBEC-like C-terminal domain
    pfam08210
    Location:135 → 308
    APOBEC_N; APOBEC-like N-terminal domain
Nucleotide Protein
Heading Accession and Version

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