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Tsr1 TSR1 20S rRNA accumulation [ Mus musculus (house mouse) ]

Gene ID: 104662, updated on 14-Dec-2022

Summary

Official Symbol
Tsr1provided by MGI
Official Full Name
TSR1 20S rRNA accumulationprovided by MGI
Primary source
MGI:MGI:2144566
See related
Ensembl:ENSMUSG00000038335 AllianceGenome:MGI:2144566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1401
Summary
Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in nucleus. Predicted to be part of preribosome, small subunit precursor. Orthologous to human TSR1 (TSR1 ribosome maturation factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 18.1), CNS E11.5 (RPKM 15.1) and 28 other tissues See more
Orthologs
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Genomic context

See Tsr1 in Genome Data Viewer
Location:
11; 11 B5
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (74788906..74800166)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (74898080..74909340)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene max binding protein Neighboring gene small G protein signaling modulator 2 Neighboring gene microRNA 6926 Neighboring gene small nucleolar RNA, C/D box 91A Neighboring gene serine racemase Neighboring gene predicted gene, 22733 Neighboring gene SMG6 nonsense mediated mRNA decay factor Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables U3 snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pre-rRNA-processing protein TSR1 homolog
Names
TSR1, 20S rRNA accumulation, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177325.3NP_796299.2  pre-rRNA-processing protein TSR1 homolog

    See identical proteins and their annotated locations for NP_796299.2

    Status: VALIDATED

    Source sequence(s)
    AK129350, BF455129, CD547366
    Consensus CDS
    CCDS36225.1
    UniProtKB/Swiss-Prot
    Q5SWD9, Q8K2F5
    Related
    ENSMUSP00000039027.8, ENSMUST00000045807.14
    Conserved Domains (5) summary
    smart00785
    Location:228309
    AARP2CN; AARP2CN (NUC121) domain
    COG5177
    Location:32774
    COG5177; Uncharacterized conserved protein [Function unknown]
    pfam04950
    Location:489772
    RIBIOP_C; 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
    cl00388
    Location:455482
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl21455
    Location:140255
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    74788906..74800166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)