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COG5 component of oligomeric golgi complex 5 [ Homo sapiens (human) ]

Gene ID: 10466, updated on 26-Nov-2021

Summary

Official Symbol
COG5provided by HGNC
Official Full Name
component of oligomeric golgi complex 5provided by HGNC
Primary source
HGNC:HGNC:14857
See related
Ensembl:ENSG00000164597 MIM:606821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDG2I; GTC90; GOLTC1
Summary
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in thyroid (RPKM 12.7), prostate (RPKM 10.2) and 25 other tissues See more
Orthologs
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Genomic context

See COG5 in Genome Data Viewer
Location:
7q22.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (107201372..107564361, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (106841817..107204365, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr7.4050 Neighboring gene PRKAR2B antisense RNA 1 Neighboring gene protein kinase cAMP-dependent type II regulatory subunit beta Neighboring gene HMG-box transcription factor 1 Neighboring gene ribosomal protein L37a pseudogene 6 Neighboring gene G protein-coupled receptor 22 Neighboring gene DUS4L-BCAP29 readthrough Neighboring gene dihydrouridine synthase 4 like Neighboring gene B cell receptor associated protein 29 Neighboring gene WBP1L pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41732, FLJ44289

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Golgi transport complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Golgi transport complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in trans-Golgi network membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
conserved oligomeric Golgi complex subunit 5
Names
13S golgi transport complex 1 90 kDa subunit
COG complex subunit 5
conserved oligomeric Golgi complex protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028095.2 RefSeqGene

    Range
    5001..367771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001161520.2NP_001154992.2  conserved oligomeric Golgi complex subunit 5 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004492, AK022835, AK314270, BC068540
    Consensus CDS
    CCDS55152.1
    Related
    ENSP00000377228.3, ENST00000393603.7
    Conserved Domains (1) summary
    pfam10392
    Location:35158
    COG5; Golgi transport complex subunit 5
  2. NM_001379511.1NP_001366440.1  conserved oligomeric Golgi complex subunit 5 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC002381, AC004492, AC004855
    Conserved Domains (1) summary
    pfam10392
    Location:35158
    COG5; Golgi transport complex subunit 5
  3. NM_001379512.1NP_001366441.1  conserved oligomeric Golgi complex subunit 5 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC002381, AC004492, AC004855
    Conserved Domains (1) summary
    pfam10392
    Location:35158
    COG5; Golgi transport complex subunit 5
  4. NM_001379513.1NP_001366442.1  conserved oligomeric Golgi complex subunit 5 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC002381, AC004492, AC004855
    Conserved Domains (1) summary
    pfam10392
    Location:35158
    COG5; Golgi transport complex subunit 5
  5. NM_001379514.1NP_001366443.1  conserved oligomeric Golgi complex subunit 5 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC002381, AC004492, AC004855
    Conserved Domains (1) summary
    pfam10392
    Location:35158
    COG5; Golgi transport complex subunit 5
  6. NM_001379515.1NP_001366444.1  conserved oligomeric Golgi complex subunit 5 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC002381, AC004492
    Conserved Domains (2) summary
    pfam10392
    Location:35158
    COG5; Golgi transport complex subunit 5
    cl00549
    Location:481559
    ABC_membrane; ABC transporter transmembrane region
  7. NM_001379516.1NP_001366445.1  conserved oligomeric Golgi complex subunit 5 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC002381, AC004492, AC004855
    Conserved Domains (1) summary
    cl22951
    Location:3581
    Vps51; Vps51/Vps67
  8. NM_006348.5NP_006339.4  conserved oligomeric Golgi complex subunit 5 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC002381, AC004492, AC004855
    Consensus CDS
    CCDS5742.1
    Related
    ENSP00000297135.4, ENST00000297135.9
    Conserved Domains (1) summary
    pfam10392
    Location:35158
    COG5; Golgi transport complex subunit 5
  9. NM_181733.4NP_859422.3  conserved oligomeric Golgi complex subunit 5 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC002381, AC004492, AC004855
    Consensus CDS
    CCDS5743.1
    Related
    ENSP00000334703.3, ENST00000347053.8
    Conserved Domains (1) summary
    pfam10392
    Location:35158
    COG5; Golgi transport complex subunit 5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    107201372..107564361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446634.1XP_024302402.1  conserved oligomeric Golgi complex subunit 5 isoform X1

    Conserved Domains (1) summary
    pfam10392
    Location:66189
    COG5; Golgi transport complex subunit 5

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_017852930.1 Reference GRCh38.p13 PATCHES

    Range
    46894..409575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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