U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC30A9 solute carrier family 30 member 9 [ Homo sapiens (human) ]

Gene ID: 10463, updated on 17-Jun-2024

Summary

Official Symbol
SLC30A9provided by HGNC
Official Full Name
solute carrier family 30 member 9provided by HGNC
Primary source
HGNC:HGNC:1329
See related
Ensembl:ENSG00000014824 MIM:604604; AllianceGenome:HGNC:1329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUEL; ZNT9; GAC63; C4orf1; BILAPES
Summary
Predicted to enable nuclear receptor coactivator activity. Involved in cellular zinc ion homeostasis and zinc ion transport. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 32.5), brain (RPKM 27.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SLC30A9 in Genome Data Viewer
Location:
4p13
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (41990530..42090461)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (41964357..42064385)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (41992547..42092478)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21510 Neighboring gene transmembrane protein 33 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:41983504-41984703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21511 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:41992428-41992647 Neighboring gene DDB1 and CUL4 associated factor 4 like 1 Neighboring gene ATPase Na+/K+ transporting subunit beta 1 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:42138326-42138861 Neighboring gene BEN domain containing 4 Neighboring gene VISTA enhancer hs847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:42153146-42153989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15391 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:42263210-42263710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21513 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:42287227-42287728 Neighboring gene uncharacterized LOC124900697

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor coactivator activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-excision repair TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitochondrion organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in zinc ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in zinc ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
proton-coupled zinc antiporter SLC30A9, mitochondrial
Names
GRIP1-dependent nuclear receptor coactivator
expressed in human embryonic lung
human embryonic lung protein
solute carrier family 30 (zinc transporter), member 9
zinc transporter 9
znT-9

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006345.4NP_006336.3  proton-coupled zinc antiporter SLC30A9, mitochondrial

    See identical proteins and their annotated locations for NP_006336.3

    Status: VALIDATED

    Source sequence(s)
    AA427879, AC113151, AY594282, BC007732, BC022981, BG323207
    Consensus CDS
    CCDS3465.1
    UniProtKB/Swiss-Prot
    Q4W5B6, Q6PML9, Q7Z5I7, Q8TBB2, Q9Y6R2
    UniProtKB/TrEMBL
    A0A0S2Z514, B2R745
    Related
    ENSP00000264451.6, ENST00000264451.12
    Conserved Domains (3) summary
    TIGR00598
    Location:124216
    rad14; DNA repair protein
    TIGR01297
    Location:254522
    CDF; cation diffusion facilitator family transporter
    pfam01545
    Location:251450
    Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    41990530..42090461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449525.1XP_047305481.1  proton-coupled zinc antiporter SLC30A9, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A0S2Z512

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    41964357..42064385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348771.1XP_054204746.1  proton-coupled zinc antiporter SLC30A9, mitochondrial isoform X1