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OLFM1 olfactomedin 1 [ Homo sapiens (human) ]

Gene ID: 10439, updated on 10-Oct-2020

Summary

Official Symbol
OLFM1provided by HGNC
Official Full Name
olfactomedin 1provided by HGNC
Primary source
HGNC:HGNC:17187
See related
Ensembl:ENSG00000130558 MIM:605366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMY; NOE1; OlfA; NOELIN1
Summary
This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 118.4), adrenal (RPKM 7.6) and 1 other tissue See more
Orthologs

Genomic context

See OLFM1 in Genome Data Viewer
Location:
9q34.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (135075505..135121184)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (137967089..138013030)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376314 Neighboring gene uncharacterized LOC105376313 Neighboring gene uncharacterized LOC102723948 Neighboring gene uncharacterized LOC401557

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available
Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
atrioventricular valve formation ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neuronal signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
noelin
Names
neuroblastoma protein
neuronal olfactomedin-related ER localized protein
olfactomedin related ER localized protein
pancortin 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282611.2NP_001269540.1  noelin isoform 4 precursor

    See identical proteins and their annotated locations for NP_001269540.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (4) has distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK290478, AL390778, BU078731
    Consensus CDS
    CCDS65184.1
    UniProtKB/Swiss-Prot
    Q99784
    Related
    ENSP00000360858.3, ENST00000371793.7
    Conserved Domains (3) summary
    smart00284
    Location:228478
    OLF; Olfactomedin-like domains
    PRK03918
    Location:92218
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam12308
    Location:54152
    Noelin-1; Neurogenesis glycoprotein
  2. NM_001282612.1NP_001269541.1  noelin isoform 5

    See identical proteins and their annotated locations for NP_001269541.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (5) has distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK096304, AL390778, BU078731
    Consensus CDS
    CCDS65183.1
    UniProtKB/Swiss-Prot
    Q99784
    Related
    ENSP00000360861.3, ENST00000371796.7
    Conserved Domains (3) summary
    smart00284
    Location:201451
    OLF; Olfactomedin-like domains
    pfam12308
    Location:27125
    Noelin-1; Neurogenesis glycoprotein
    cl25732
    Location:65191
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_006334.4NP_006325.1  noelin isoform 2 precursor

    See identical proteins and their annotated locations for NP_006325.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus when compared to isoform 1.
    Source sequence(s)
    AI656802, D82343, DB069120
    Consensus CDS
    CCDS6987.1
    UniProtKB/Swiss-Prot
    Q99784
    UniProtKB/TrEMBL
    Q6IMJ7
    Related
    ENSP00000277415.11, ENST00000277415.15
    Conserved Domains (1) summary
    pfam12308
    Location:36134
    Noelin-1; Neurogenesis glycoprotein
  4. NM_014279.5NP_055094.1  noelin isoform 1 precursor

    See identical proteins and their annotated locations for NP_055094.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC011741, BU078731, BX461034, DA795630
    Consensus CDS
    CCDS6986.1
    UniProtKB/Swiss-Prot
    Q99784
    UniProtKB/TrEMBL
    Q6IMJ8
    Related
    ENSP00000252854.4, ENST00000252854.8
    Conserved Domains (3) summary
    smart00284
    Location:210460
    OLF; Olfactomedin-like domains
    pfam12308
    Location:36134
    Noelin-1; Neurogenesis glycoprotein
    cl25732
    Location:74200
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    135075505..135121184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_058199.2: Suppressed sequence

    Description
    NM_058199.2: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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