Arl1 ADP-ribosylation factor-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arl1provided by MGI
Official Full Name: ADP-ribosylation factor-like 1provided by MGI
Primary source: MGI:MGI:99436
See related: Ensembl:ENSMUSG00000060904 AllianceGenome:MGI:99436
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310008D22Rik
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activity; and enzyme activator activity. Predicted to be involved in several processes, including activation of phospholipase D activity; protein localization to Golgi apparatus; and retrograde transport, endosome to Golgi. Located in cytoplasm. Is expressed in genitourinary system and inner ear. Orthologous to human ARL1 (ADP ribosylation factor like GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 60.6), placenta adult (RPKM 54.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10; 10 C1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (88566720..88579956)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (88730920..88744094)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi.
Title: Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136281 (e-PCR)
- UniSTS:210274

NoName (e-PCR)
- UniSTS:492521

Homology

Homologs of the Arl1 gene: The Arl1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 487 organisms have orthologs with human gene Arl1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi vesicle transport	ISO Inferred from Sequence Orthology more info
involved_in activation of phospholipase D activity	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in toxin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylation factor-like protein 1

Names: ADP-ribosylation-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025859.3 → NP_080135.2 ADP-ribosylation factor-like protein 1

See identical proteins and their annotated locations for NP_080135.2

Status: PROVISIONAL

Source sequence(s)

AK010732

Consensus CDS

CCDS36025.1

UniProtKB/Swiss-Prot

P41276, P61211

UniProtKB/TrEMBL

A0A6P5QLW4, Q14AC7

Related

ENSMUSP00000111942.3, ENSMUST00000116234.9

Conserved Domains (1) summary

cd04151
Location:19 → 176

Arl1; ADP ribosylation factor 1 (Arf1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

88566720..88579956

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244800.2 → XP_030100660.1 ADP-ribosylation factor-like protein 1 isoform X1

UniProtKB/Swiss-Prot

P41276

UniProtKB/TrEMBL

A0A6P5QLW4, Q14AC7

Conserved Domains (1) summary

cd04151
Location:19 → 176

Arl1; ADP ribosylation factor 1 (Arf1)