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TUBGCP3 tubulin gamma complex associated protein 3 [ Homo sapiens (human) ]

Gene ID: 10426, updated on 7-Jul-2019

Summary

Official Symbol
TUBGCP3provided by HGNC
Official Full Name
tubulin gamma complex associated protein 3provided by HGNC
Primary source
HGNC:HGNC:18598
See related
Ensembl:ENSG00000126216 MIM:617818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
104p; ALP6; GCP3; Spc98; SPBC98; Spc98p; Grip104
Expression
Ubiquitous expression in testis (RPKM 8.5), ovary (RPKM 6.0) and 25 other tissues See more
Orthologs

Genomic context

See TUBGCP3 in Genome Data Viewer
Location:
13q34
Exon count:
26
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (112485005..112606469, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (113139319..113242494, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370373 Neighboring gene uncharacterized LOC105370372 Neighboring gene sperm acrosome associated 7 Neighboring gene ATP11A upstream neighbor Neighboring gene uncharacterized LOC102725228

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
NHGRI GWA Catalog

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Centrosome maturation, organism-specific biosystem (from REACTOME)
    Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Recruitment of NuMA to mitotic centrosomes, organism-specific biosystem (from REACTOME)
    Recruitment of NuMA to mitotic centrosomes, organism-specific biosystemThe NuMA protein, which functions as a nuclear matrix protein in interphase (Merdes and Cleveland 1998), redistributes to the cytoplasm following nuclear envelope breakdown where it plays an essen...
  • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
    Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule nucleation NAS
Non-traceable Author Statement
more info
PubMed 
microtubule nucleation by interphase microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single fertilization NAS
Non-traceable Author Statement
more info
PubMed 
spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome NAS
Non-traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-tubulin small complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
polar microtubule IDA
Inferred from Direct Assay
more info
PubMed 
spindle NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
gamma-tubulin complex component 3
Names
gamma-ring complex protein 104 kDa
spindle pole body protein Spc98 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286277.2NP_001273206.1  gamma-tubulin complex component 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA720688, AF042378, AK302537, AK314785, AL139384, BC046634
    UniProtKB/Swiss-Prot
    Q96CW5
    UniProtKB/TrEMBL
    B4DYP7
    Conserved Domains (1) summary
    pfam04130
    Location:243753
    Spc97_Spc98; Spc97 / Spc98 family
  2. NM_001286278.2NP_001273207.1  gamma-tubulin complex component 3 isoform 3

    See identical proteins and their annotated locations for NP_001273207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' exons and contains an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK314785, BC013781
    Consensus CDS
    CCDS66584.1
    UniProtKB/Swiss-Prot
    Q96CW5
    Related
    ENSP00000364821.3, ENST00000375669.7
    Conserved Domains (1) summary
    pfam04130
    Location:253763
    Spc97_Spc98; Spc97 / Spc98 family
  3. NM_001286279.1NP_001273208.1  gamma-tubulin complex component 3 isoform 4

    See identical proteins and their annotated locations for NP_001273208.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' exons and its 3' terminal exon extends past a splice site that is used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK314785, BC007763, BP381545
    Consensus CDS
    CCDS73599.1
    UniProtKB/Swiss-Prot
    Q96CW5
    UniProtKB/TrEMBL
    A0A087WU06
    Related
    ENSP00000478276.1, ENST00000464139.5
    Conserved Domains (1) summary
    pfam04130
    Location:253389
    Spc97_Spc98; Spc97 / Spc98 family
  4. NM_006322.6NP_006313.1  gamma-tubulin complex component 3 isoform 1

    See identical proteins and their annotated locations for NP_006313.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA720688, AF042378, BC046634
    Consensus CDS
    CCDS9525.1
    UniProtKB/Swiss-Prot
    Q96CW5
    Related
    ENSP00000261965.3, ENST00000261965.8
    Conserved Domains (1) summary
    pfam04130
    Location:253763
    Spc97_Spc98; Spc97 / Spc98 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    112485005..112606469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020323.2XP_016875812.1  gamma-tubulin complex component 3 isoform X3

    Conserved Domains (1) summary
    pfam04130
    Location:24534
    Spc97_Spc98; Spc97 / Spc98 family
  2. XM_011537462.2XP_011535764.1  gamma-tubulin complex component 3 isoform X2

    Conserved Domains (1) summary
    pfam04130
    Location:253663
    Spc97_Spc98; Spc97 / Spc98 family
  3. XM_005268293.2XP_005268350.1  gamma-tubulin complex component 3 isoform X1

    Conserved Domains (1) summary
    pfam04130
    Location:253763
    Spc97_Spc98; Spc97 / Spc98 family

RNA

  1. XR_001749455.2 RNA Sequence

    Related
    ENST00000649778.1

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187592.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    285981..305687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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