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Ces1d carboxylesterase 1D [ Mus musculus (house mouse) ]

Gene ID: 104158, updated on 14-May-2024

Summary

Official Symbol
Ces1dprovided by MGI
Official Full Name
carboxylesterase 1Dprovided by MGI
Primary source
MGI:MGI:2148202
See related
Ensembl:ENSMUSG00000056973 AllianceGenome:MGI:2148202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TGH; Ces3
Summary
Enables sterol esterase activity and triglyceride lipase activity. Involved in acylglycerol catabolic process. Acts upstream of or within several processes, including cellular lipid catabolic process; temperature homeostasis; and very-low-density lipoprotein particle assembly. Located in cytosol; endoplasmic reticulum lumen; and lipid droplet. Is expressed in several structures, including cochlear duct; gut; liver; nose; and respiratory system. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 175.8), liver adult (RPKM 134.4) and 8 other tissues See more
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Genomic context

See Ces1d in Genome Data Viewer
Location:
8 C5; 8 45.05 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (93892700..93924432, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93166072..93197804, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 1C Neighboring gene predicted gene 45910 Neighboring gene STARR-seq mESC enhancer starr_22332 Neighboring gene carboxylesterase 1E Neighboring gene carboxylesterase 1F

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables carboxylic ester hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty-acyl-ethyl-ester synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables retinyl-palmitate esterase activity ISO
Inferred from Sequence Orthology
more info
 
enables sterol esterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sterol esterase activity ISO
Inferred from Sequence Orthology
more info
 
enables triglyceride lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in acylglycerol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to cold IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within circadian temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cytosolic lipolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in medium-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bile acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to toxic substance TAS
Traceable Author Statement
more info
PubMed 
involved_in reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within short-chain fatty acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within very-low-density lipoprotein particle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carboxylesterase 1D
Names
FAEE synthase
carboxylesterase 3
fatty acid ethyl ester synthase
triacylglycerol hydrolase
NP_444430.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053200.2NP_444430.2  carboxylesterase 1D precursor

    See identical proteins and their annotated locations for NP_444430.2

    Status: VALIDATED

    Source sequence(s)
    AA522194, AK078879, CJ133999
    Consensus CDS
    CCDS22528.1
    UniProtKB/Swiss-Prot
    Q8VCT4, Q91ZV9, Q924V8, Q9ULY1
    Related
    ENSMUSP00000034172.8, ENSMUST00000034172.8
    Conserved Domains (2) summary
    COG0657
    Location:121239
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:24545
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    93892700..93924432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)