Etv5 ets variant 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Etv5provided by MGI
Official Full Name: ets variant 5provided by MGI
Primary source: MGI:MGI:1096867
See related: Ensembl:ENSMUSG00000013089 AllianceGenome:MGI:1096867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ERM; 1110005E01Rik; 8430401F14Rik
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including neuromuscular synaptic transmission; regulation of branching involved in mammary gland duct morphogenesis; and skeletal muscle acetylcholine-gated channel clustering. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Used to study T-cell adult acute lymphocytic leukemia. Orthologous to human ETV5 (ETS variant transcription factor 5). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Broad expression in genital fat pad adult (RPKM 31.7), lung adult (RPKM 30.1) and 22 other tissues See more
Orthologs: all
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Genomic context

Location:: 16 B1; 16 13.3 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (22200063..22258320, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (22381313..22439570, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression.
Title: ETV5 promotes lupus pathogenesis and follicular helper T cell differentiation by inducing osteopontin expression.
Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity.
Title: Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity.
Establishment of Etv5 gene knockout mice as a recipient model for spermatogonial stem cell transplantation.
Title: Establishment of Etv5 gene knockout mice as a recipient model for spermatogonial stem cell transplantation.
Etv5 safeguards trophoblast stem cells differentiation from mouse EPSCs by regulating fibroblast growth factor receptor 2.
Title: Etv5 safeguards trophoblast stem cells differentiation from mouse EPSCs by regulating fibroblast growth factor receptor 2.
ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway.
Title: ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway.
Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
Title: Etv transcription factors functionally diverge from their upstream FGF signaling in lens development.
Derepression of Etv5 increases Hobit expression in Cic -deficient CD8+ T cells and consequently enhances CD8+ T memory cell formation in liver, thereby leading to liver injury.
Title: The Capicua/ETS Translocation Variant 5 Axis Regulates Liver-Resident Memory CD8(+) T-Cell Development and the Pathogenesis of Liver Injury.
Study found that ETV5 increased acyl ghrelin but not its total production; through the enhanced expression of GOAT enzyme. ETV5 transactivated GOAT promoter, leading to the subsequent increase of its expression. mTORC1 signaling inhibited the expression of ETV5 which deficiency attenuated the effect of mTORC1 signaling on GOAT/ghrelin. Therefore, ETV5 is a new transcription factor regulating GOAT expression.
Title: ETV5 regulates GOAT/ghrelin system in an mTORC1-dependent manner.
Etv5 can positively regulate primitive endoderm specification through regulating Gata6 and negatively regulate epiblast specification by inhibiting Fgf5 expression.
Title: The oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation.
CIC-ETV5 axis is critical for regulation of follicular helper T cell development
Title: Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (4)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Etv5 (e-PCR), detects polymorphism
- UniSTS:547917

Etv5 (e-PCR), detects polymorphism
- UniSTS:536522

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line stem cell asymmetric division	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle acetylcholine-gated channel clustering	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ETS translocation variant 5

Names: ets variant gene 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001358428.1 → NP_001345357.1 ETS translocation variant 5

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC154605, CT009627

Consensus CDS

CCDS37299.1

UniProtKB/Swiss-Prot

Q3TG49, Q8C0F3, Q9CXC9, Q9JHB1

UniProtKB/TrEMBL

Q8BJR1

Conserved Domains (2) summary

smart00413
Location:367 → 452

ETS; erythroblast transformation specific domain

pfam04621
Location:2 → 366

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain
NM_023794.2 → NP_076283.2 ETS translocation variant 5

See identical proteins and their annotated locations for NP_076283.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC034680

Consensus CDS

CCDS37299.1

UniProtKB/Swiss-Prot

Q3TG49, Q8C0F3, Q9CXC9, Q9JHB1

UniProtKB/TrEMBL

Q8BJR1

Related

ENSMUSP00000078551.7, ENSMUST00000079601.13

Conserved Domains (2) summary

smart00413
Location:367 → 452

ETS; erythroblast transformation specific domain

pfam04621
Location:2 → 366

ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain