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Wdr7 WD repeat domain 7 [ Mus musculus (house mouse) ]

Gene ID: 104082, updated on 5-Mar-2024

Summary

Official Symbol
Wdr7provided by MGI
Official Full Name
WD repeat domain 7provided by MGI
Primary source
MGI:MGI:1860197
See related
Ensembl:ENSMUSG00000040560 AllianceGenome:MGI:1860197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRAG; mKIAA0541
Summary
Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in synaptic vesicle. Predicted to be active in cytoplasm. Is expressed in nervous system; sensory organ; and testis. Orthologous to human WDR7 (WD repeat domain 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 10.9), cortex adult (RPKM 9.8) and 28 other tissues See more
Orthologs
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Genomic context

See Wdr7 in Genome Data Viewer
Location:
18 E1; 18 37.09 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (63841731..64122831)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (63708498..63989760)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8721 Neighboring gene STARR-positive B cell enhancer ABC_E9981 Neighboring gene STARR-positive B cell enhancer ABC_E4251 Neighboring gene thioredoxin-like 1 Neighboring gene predicted gene, 41754 Neighboring gene predicted gene, 41753 Neighboring gene STARR-positive B cell enhancer mm9_chr18:63930880-63931180 Neighboring gene STARR-seq mESC enhancer starr_44794 Neighboring gene STARR-seq mESC enhancer starr_44796 Neighboring gene STARR-seq mESC enhancer starr_44797 Neighboring gene proteasome (prosome, macropain) subunit, beta type 1 pseudogene Neighboring gene predicted gene, 24384 Neighboring gene STARR-seq mESC enhancer starr_44798 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_44800 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand Neighboring gene STARR-seq mESC enhancer starr_44802 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
WD repeat-containing protein 7
Names
TGF-beta resistance associated
TGF-beta resistance-associated protein TRAG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014981.1NP_001014981.1  WD repeat-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_001014981.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC102040, AC102132, AC157903
    Consensus CDS
    CCDS50307.1
    UniProtKB/Swiss-Prot
    Q059Q1, Q3U440, Q80TY3, Q920I9, Q920J0
    Related
    ENSMUSP00000072509.6, ENSMUST00000072726.7
    Conserved Domains (3) summary
    COG2319
    Location:341592
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:2262
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:408592
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001360837.1NP_001347766.1  WD repeat-containing protein 7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter, compared to isoform 1.
    Source sequence(s)
    AC102040, AC102132, AC157903
    Consensus CDS
    CCDS89260.1
    Related
    ENSMUSP00000158252.2, ENSMUST00000236879.2
    Conserved Domains (2) summary
    sd00039
    Location:2262
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:408592
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    63841731..64122831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525478.5XP_006525541.1  WD repeat-containing protein 7 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:2262
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:408592
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...