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MYCNOS MYCN opposite strand [ Homo sapiens (human) ]

Gene ID: 10408, updated on 28-Apr-2025

Summary

Official Symbol
MYCNOSprovided by HGNC
Official Full Name
MYCN opposite strandprovided by HGNC
Primary source
HGNC:HGNC:16911
See related
Ensembl:ENSG00000233718 MIM:605374; AllianceGenome:HGNC:16911
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCYM; NYCM; N-CYM; MYCN-AS1
Summary
This gene is transcribed in antisense to the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog gene (MYCN). It is thought to encode a small, novel protein that stabilizes MYCN, prevents apoptosis, and promotes cell proliferation. Transcripts at this locus may also act directly as functional RNAs to recruit transcriptional regulators to the promoter of MYCN and stimulate transcription of this oncogene. This gene therefore functions through both RNA and protein products. [provided by RefSeq, Aug 2016]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See MYCNOS in Genome Data Viewer
Location:
2p24.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (15936265..15942433, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (15967896..15974065, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (16076387..16082555, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene MYCN upstream transcript Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:16078668-16079225 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:16080270-16080800 Neighboring gene RNA, 7SL, cytoplasmic 104, pseudogene Neighboring gene MYCN proto-oncogene, bHLH transcription factor Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:16120447-16121234 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:16140957-16141151 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:16153570-16154181 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:16174407-16174907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:16197762-16198262 Neighboring gene gastric cancer associated transcript 3

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Other Names

  • DNA-binding transcriptional activator NCYM
  • MYCN antisense RNA 1
  • MYCN opposite strand/antisense RNA (non-protein coding)
  • N-myc opposite strand
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived opposite strand

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_110230.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010145
    Related
    ENST00000641263.1
  2. NR_161162.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010145, KF456635
  3. NR_161163.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010145, KF456635
    Related
    ENST00000641534.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    15936265..15942433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    15967896..15974065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)