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MYCNOS MYCN opposite strand [ Homo sapiens (human) ]

Gene ID: 10408, updated on 9-Sep-2022

Summary

Official Symbol
MYCNOSprovided by HGNC
Official Full Name
MYCN opposite strandprovided by HGNC
Primary source
HGNC:HGNC:16911
See related
Ensembl:ENSG00000233718 MIM:605374; AllianceGenome:HGNC:16911
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCYM; NYCM; N-CYM; MYCN-AS1
Summary
This gene is transcribed in antisense to the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog gene (MYCN). It is thought to encode a small, novel protein that stabilizes MYCN, prevents apoptosis, and promotes cell proliferation. Transcripts at this locus may also act directly as functional RNAs to recruit transcriptional regulators to the promoter of MYCN and stimulate transcription of this oncogene. This gene therefore functions through both RNA and protein products. [provided by RefSeq, Aug 2016]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See MYCNOS in Genome Data Viewer
Location:
2p24.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (15936265..15942433, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (15967896..15974065, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (16076387..16082555, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene MYCN upstream transcript Neighboring gene MYCN proto-oncogene, bHLH transcription factor Neighboring gene RNA, 7SL, cytoplasmic 104, pseudogene Neighboring gene Sharpr-MPRA regulatory region 8208

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Other Names

  • DNA-binding transcriptional activator NCYM
  • MYCN antisense RNA 1
  • MYCN opposite strand/antisense RNA (non-protein coding)
  • N-myc opposite strand
  • v-myc myelocytomatosis viral related oncogene, neuroblastoma derived opposite strand

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_110230.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010145
    Related
    ENST00000641263.1
  2. NR_161162.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010145, KF456635
    Related
    ENST00000419083.6
  3. NR_161163.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010145, KF456635

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    15936265..15942433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    15967896..15974065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)