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Gck glucokinase [ Mus musculus (house mouse) ]

Gene ID: 103988, updated on 31-Jan-2019

Summary

Official Symbol
Gckprovided by MGI
Official Full Name
glucokinaseprovided by MGI
Primary source
MGI:MGI:1270854
See related
Ensembl:ENSMUSG00000041798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gk; GLK; HK4; HKIV; HXKP; Hlb62; MODY2; Gls006
Expression
Biased expression in liver adult (RPKM 44.2), liver E18 (RPKM 7.5) and 1 other tissue See more
Orthologs

Genomic context

See Gck in Genome Data Viewer
Location:
11 A1; 11 3.88 cM
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (5900816..5950081, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (5800826..5849602, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene AE binding protein 1 Neighboring gene polymerase (DNA directed), delta 2, regulatory subunit Neighboring gene myosin, light polypeptide 7, regulatory Neighboring gene predicted gene 11967 Neighboring gene YKT6 v-SNARE homolog (S. cerevisiae) Neighboring gene calcium/calmodulin-dependent protein kinase II, beta Neighboring gene predicted gene, 40812

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ADP binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
glucokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucokinase activity ISO
Inferred from Sequence Orthology
more info
 
glucose binding ISO
Inferred from Sequence Orthology
more info
 
hexokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NADP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion import IMP
Inferred from Mutant Phenotype
more info
PubMed 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
carbohydrate phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
carbohydrate phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
carbohydrate phosphorylation ISO
Inferred from Sequence Orthology
more info
 
cellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to leptin stimulus ISO
Inferred from Sequence Orthology
more info
 
detection of glucose ISO
Inferred from Sequence Orthology
more info
 
fructose 2,6-bisphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolytic process ISO
Inferred from Sequence Orthology
more info
 
lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of potassium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
second-messenger-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
 
basal cortex ISO
Inferred from Sequence Orthology
more info
 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glucokinase
Names
HK IV
hexokinase type IV
hexokinase-4
hexokinase-D
NP_001274315.1
NP_034422.2
XP_006514506.1
XP_006514507.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287386.1NP_001274315.1  glucokinase isoform 2

    See identical proteins and their annotated locations for NP_001274315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate first exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is expressed in liver and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL645469
    Consensus CDS
    CCDS70135.1
    UniProtKB/Swiss-Prot
    P52792
    UniProtKB/TrEMBL
    Q5SVI6
    Related
    ENSMUSP00000105448.2, ENSMUST00000109823.8
    Conserved Domains (3) summary
    COG5026
    Location:16458
    COG5026; Hexokinase [Carbohydrate transport and metabolism]
    pfam00349
    Location:16215
    Hexokinase_1; Hexokinase
    pfam03727
    Location:221455
    Hexokinase_2; Hexokinase
  2. NM_010292.5NP_034422.2  glucokinase isoform 1

    See identical proteins and their annotated locations for NP_034422.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the isoform expressed in pancreatic islet beta cells.
    Source sequence(s)
    AL645469
    Consensus CDS
    CCDS24409.1
    UniProtKB/Swiss-Prot
    P52792
    UniProtKB/TrEMBL
    Q5SVI5
    Related
    ENSMUSP00000099984.3, ENSMUST00000102920.3
    Conserved Domains (3) summary
    COG5026
    Location:8458
    COG5026; Hexokinase [Carbohydrate transport and metabolism]
    pfam00349
    Location:15215
    Hexokinase_1; Hexokinase
    pfam03727
    Location:221455
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    5900816..5950081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514444.1XP_006514507.1  glucokinase isoform X2

    Conserved Domains (2) summary
    pfam00349
    Location:15215
    Hexokinase_1; Hexokinase
    pfam03727
    Location:221418
    Hexokinase_2; Hexokinase
  2. XM_006514443.3XP_006514506.1  glucokinase isoform X1

    Conserved Domains (2) summary
    pfam00349
    Location:16215
    Hexokinase_1; Hexokinase
    pfam03727
    Location:221418
    Hexokinase_2; Hexokinase
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