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CACNG3 calcium voltage-gated channel auxiliary subunit gamma 3 [ Homo sapiens (human) ]

Gene ID: 10368, updated on 13-Mar-2020

Summary

Official Symbol
CACNG3provided by HGNC
Official Full Name
calcium voltage-gated channel auxiliary subunit gamma 3provided by HGNC
Primary source
HGNC:HGNC:1407
See related
Ensembl:ENSG00000006116 MIM:606403
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010]
Expression
Restricted expression toward brain (RPKM 19.9) See more
Orthologs

Genomic context

See CACNG3 in Genome Data Viewer
Location:
16p12.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (24256335..24362412)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (24266874..24373737)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene protein kinase C beta Neighboring gene microRNA 1273h Neighboring gene long intergenic non-protein coding RNA 2194 Neighboring gene RNA, U7 small nuclear 24 pseudogene Neighboring gene uncharacterized LOC105371143

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 
voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated calcium channel activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
calcium ion transport NAS
Non-traceable Author Statement
more info
PubMed 
cardiac conduction TAS
Traceable Author Statement
more info
 
neurotransmitter receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of AMPA receptor activity IEA
Inferred from Electronic Annotation
more info
 
postsynaptic neurotransmitter receptor diffusion trapping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein targeting ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of AMPA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of AMPA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transmission of nerve impulse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
somatodendritic compartment ISS
Inferred from Sequence or Structural Similarity
more info
 
voltage-gated calcium channel complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
voltage-dependent calcium channel gamma-3 subunit
Names
TARP gamma-3
calcium channel, voltage-dependent, gamma subunit 3
neuronal voltage-gated calcium channel gamma-3 subunit
transmembrane AMPAR regulatory protein gamma-3
voltage-gated calcium channel gamma subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006539.4NP_006530.1  voltage-dependent calcium channel gamma-3 subunit

    See identical proteins and their annotated locations for NP_006530.1

    Status: REVIEWED

    Source sequence(s)
    AC004125
    Consensus CDS
    CCDS10620.1
    UniProtKB/Swiss-Prot
    O60359
    Related
    ENSP00000005284.3, ENST00000005284.3
    Conserved Domains (1) summary
    cl21598
    Location:6196
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    24256335..24362412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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